40161-55-5Relevant articles and documents
Synthesis method of 2-bromo-5-fluorobenzotrifluoride
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Paragraph 0025; 0027-0028; 0030-0031; 0033-0034; 0036-0037, (2020/07/15)
The invention relates to a synthesis method of 2-bromo-5-fluorobenzotrifluoride. The synthesis method comprises the following steps: with benzotrifluoride as a raw material, mixing benzotrifluoride with sulfuric acid, potassium bromide, cuprous bromide and a catalyst, and carrying out a bromination reaction to obtain 2-bromobenzotrifluoride; putting the obtained 2-bromobenzotrifluoride into a DMSOsolvent, adding potassium fluoride and KCoF4, and carrying out a fluorination reaction so as to obtain 2-bromo-5-fluorobenzotrifluoride. According to the method, trifluorotoluene is used as the raw material; the method is a brand-new synthetic route; bromination and fluorination conditions are mild; reaction yield is high; used raw materials are easy to purchase and low in price; and thus, the method has relatively high industrial application value.
Normal-temperature catalyzed synthesis of 2-bromo-5-fluorobenzotrifluoride
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Paragraph 0028; 0029; 0030; 0031; 0032; 0033; 0034-0043, (2017/12/04)
The invention discloses a method for preparing 2-bromo-5-fluorobenzotrifluoride. In the method, fluorobenzotrifluoride is used as a raw material, bromine is used as a brominating agent, and the 2-bromo-5-fluorobenzotrifluoride is synthesized in the presence of sulfuric acid and a composite catalyst at normal temperature. By means of the method, the yield reaches 90.0% or above, the purity reaches 99.0% or above, the raw materials used in the reaction process are convenient to purchase, the production cost is low, the waste acid obtained in the reaction process can be recycled, the post-treatment is easy, the reaction conditions are mild, and the method has good economic benefits and social benefits.
2-bromo-5- fluorine three fluorine methylbenzene preparation method
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Paragraph 0112-0134, (2017/04/03)
The invention discloses a method for preparing 2-bromine-5-trifluorotoluene chloride. The method comprises the following step: under an anhydrous condition and in an organic solvent, performing cracking reaction on an anhydrous compound 1 or a compound 1', thereby preparing 2-bromine-5-trifluorotoluene chloride. According to the method, the reaction of an upper amino protecting group of m-trifluoromethyl phenylamine, the bromination reaction and the reaction of removing the amino protecting group can be all performed in one same reaction kettle without transferring or storing materials. The raw materials used in the method disclosed by the invention are cheap and easy to obtain, the reaction step is short, the reaction condition is gentle, the utilization rate of bromine is high, and the positioning selectivity of bromine feeding is high, so that a final product is low in isomeride impurity, high in reaction conversion rate, high in yield, high in product purity, low in production cost is low and applicable to industrialization production. The compound 1 and compound 1' are as shown in the specification.