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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-Bromo-5-fluorobenzotrifluoride Manufacturer/High quality/Best price/In stock

Cas:40161-55-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Bromo-5-Fluorobenzotrifluoride with high purity

Cas:40161-55-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed, dr

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-Bromo-5-Fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 40161-55-5 with best quality

Cas:40161-55-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: 1-Bromo-4-fluoro-2-(trifluoromethyl)benzene Synonyms: 2-bromo-5-fluorobenzotrifluoride CAS:40161-55-5 MF: C7H3BrF4 Appearance: colorless transparent liquid Storage: Preserve in well-closed, light-resistant and airtight containers. Pack

1-Bromo-4-fluoro-2-(trifluoromethyl)benzene

Cas:40161-55-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Bromo-5-fluorobenzotrifluoride 40161-55-5

Cas:40161-55-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2-Bromo-5-fluorobenzotrifluoride CAS:40161-55-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality

2-Bromo-5-fluorobenzotrifluoride CAS:40161-55-5

Cas:40161-55-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:40161-55-5

Cas:40161-55-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Bromo-5-Fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

Cas:40161-55-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2-Bromo-5-Fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

YUNBIO TECH CO.,LTD

Our Strength:-Flexible: We work in small teams with rapid communication channels. Respond quickly and efficiently to customer and market needs.-Innovative: We are focusing on the development of new products and keep close relationships with our custo

2-BROMO-5-FLUOROBENZOTRIFLUORIDE

Cas:40161-55-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

2-Bromo-5-fluorobenzotrifluoride Basic information Product Name: 2-Bromo-5-fluorobenzotrifluoride Synonyms: 4-FLUORO-2-(TRIFLUOROMETHYL)BROMOBENZ

40161-55-5 C7H3BrF4 2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

2-Bromo-5-fluorobenzotrifluoride Basic information Product Name: 2-Bromo-5-fluorobenzotrifluoride Synonyms: 4-FLUORO-2-(TRIFLUOROMETHYL)BROMOBENZENE;2-BROMO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE;2-BROMO-5-FLUOROBENZOTRIFLUORIDE;1-BROMO-4-FLUORO-2-(

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

Cas:40161-55-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

Cas:40161-55-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

Cas:40161-55-5

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-Bromo-5-fluorobenzotrifluoride

Cas:40161-55-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

o-trifluoromethylphenyl bromide
392-83-6

o-trifluoromethylphenyl bromide

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With potassium fluoride; potassium tetrafluorocobaltate In dimethyl sulfoxide for 5h; Reflux;96.7%
Multi-step reaction with 3 steps
1.1: nitric acid; sulfuric acid / 50 - 60 °C
2.1: piperazine; hydrogen / methanol / 80 - 90 °C / 6000.6 - 7500.75 Torr
3.1: hydrogen fluoride; potassium fluoride; sodium nitrite / 0.5 h / -10 - 5 °C
3.2: 60 °C
View Scheme
3-fluoro-trifluoromethylbenzene
401-80-9

3-fluoro-trifluoromethylbenzene

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With ferric(III) bromide; sulfuric acid; tetrabutylammomium bromide; bromine; lithium bromide at 20 - 25℃; for 8h; Temperature;93.09%
With N-Bromosuccinimide; sulfuric acid; tetrabutylammomium bromide; bromine; ammonium bromide at 20℃; under 760.051 Torr;92.3%
4-bromo-3-(trifluoromethyl)aniline
393-36-2

4-bromo-3-(trifluoromethyl)aniline

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Stage #1: 4-bromo-3-(trifluoromethyl)aniline With potassium fluoride; hydrogen fluoride; sodium nitrite at -10 - 5℃; for 0.5h;
Stage #2: at 60℃;
86.8%
Stage #1: 4-bromo-3-(trifluoromethyl)aniline With hydrogenchloride In water at 25℃; for 3h;
Stage #2: With sodium nitrite In water at 0℃; Concentration; Reagent/catalyst; Solvent; Temperature; Further stages;
82%
With hydrogen fluoride; sodium nitrite at -10 - 125℃; for 1.5h; Autoclave;80%
N-acetyl-3-trifluoromethylbenzenamine
351-36-0

N-acetyl-3-trifluoromethylbenzenamine

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; hydrogen bromide; dihydrogen peroxide / 0.5 h / 25 °C / Inert atmosphere
2: hydrogenchloride / water / 90 °C
3: sodium nitrite; hydrogen fluoride / 1.5 h / -10 - 125 °C / Autoclave
View Scheme
Multi-step reaction with 3 steps
1.1: sodium chlorate; acetic acid; iron; bromine / water / 11 h / 65 °C
2.1: sodium hydroxide / methanol / 5 h / 90 °C
3.1: hydrogenchloride / water / 3 h / 25 °C
3.2: 0 °C
View Scheme
N-(4-bromo-3-trifluoromethylphenyl)acetamide
41513-05-7

N-(4-bromo-3-trifluoromethylphenyl)acetamide

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water / 90 °C
2: sodium nitrite; hydrogen fluoride / 1.5 h / -10 - 125 °C / Autoclave
View Scheme
3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 1 h / 60 °C
2.1: sodium chlorate; acetic acid; iron; bromine / water / 11 h / 65 °C
3.1: sodium hydroxide / methanol / 5 h / 90 °C
4.1: hydrogenchloride / water / 3 h / 25 °C
4.2: 0 °C
View Scheme
2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogen bromide; sodium nitrite / water / 0.33 h / 0 - 5 °C
1.2: 0.33 h / 20 °C
2.1: nitric acid; sulfuric acid / 50 - 60 °C
3.1: piperazine; hydrogen / methanol / 80 - 90 °C / 6000.6 - 7500.75 Torr
4.1: hydrogen fluoride; potassium fluoride; sodium nitrite / 0.5 h / -10 - 5 °C
4.2: 60 °C
View Scheme
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

(2R)-methylpiperazine
75336-86-6

(2R)-methylpiperazine

(3R)-1-(4-fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine
946399-84-4

(3R)-1-(4-fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine

Conditions
ConditionsYield
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene Buchwald amination; regioselective reaction;100%
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 100℃; for 5h; Inert atmosphere;99%
With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 105℃; for 3.5h; Inert atmosphere;98%
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 100℃; for 5h; Buchwald amination;73%
With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 100 - 110℃; for 3 - 5h; Product distribution / selectivity;33.6%
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

tert-butyl 4-(4-fluoro-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate
946399-68-4

tert-butyl 4-(4-fluoro-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 110℃; for 0.5h; Microwave irradiation;100%
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 110℃; for 0.5h; Buchwald amination; Microwave irradiation;100%
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 100℃; for 16h; Inert atmosphere;83%
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

isobutyryl chloride
79-30-1

isobutyryl chloride

1-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpropan-1-one

1-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpropan-1-one

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene With isopropylmagnesium chloride In tetrahydrofuran; tert-butyl methyl ether at 20℃; for 1.5h; Inert atmosphere;
Stage #2: isobutyryl chloride In tert-butyl methyl ether at 20℃; for 3h; Inert atmosphere;
97.6%
Stage #1: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene With isopropylmagnesium chloride In tetrahydrofuran; toluene at 25 - 30℃; for 1h; Large scale;
Stage #2: isobutyryl chloride With copper(l) chloride In tetrahydrofuran; toluene at 25 - 40℃; for 1.5h; Temperature; Large scale;
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

acetyl chloride
75-36-5

acetyl chloride

1-(4-fluoro-2-(trifluoromethyl)phenyl)ethan-1-one

1-(4-fluoro-2-(trifluoromethyl)phenyl)ethan-1-one

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene With isopropylmagnesium chloride In tetrahydrofuran; tert-butyl methyl ether at 25 - 30℃; for 0.5h; Large scale;
Stage #2: acetyl chloride With copper(l) chloride In tetrahydrofuran; tert-butyl methyl ether at 38 - 42℃; for 1h; Solvent; Temperature; Reagent/catalyst; Large scale;
96.4%
Stage #1: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene With isopropyl chloride; magnesium; isopropyl bromide In tetrahydrofuran; toluene at 20 - 60℃;
Stage #2: acetyl chloride With copper(l) chloride In tetrahydrofuran; toluene at -5℃; for 2h; Temperature;
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

(E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate
1622308-34-2

(E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

(E)-tert-butyl 3-(4-((2-(4-fluoro-2-(trifluoromethyl)phenyl)-6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate
1622308-62-6

(E)-tert-butyl 3-(4-((2-(4-fluoro-2-(trifluoromethyl)phenyl)-6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

Conditions
ConditionsYield
With chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 150℃; for 2h; Microwave irradiation; Sealed tube; Inert atmosphere;94%
carbon dioxide
124-38-9

carbon dioxide

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

4-fluoro-2-trifluoromethylbenzoic acid
141179-72-8

4-fluoro-2-trifluoromethylbenzoic acid

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene With iodine; magnesium In tetrahydrofuran at 50℃; for 1h; Inert atmosphere; Cooling;
Stage #2: carbon dioxide In tetrahydrofuran at 5 - 25℃; for 2h; Solvent; Temperature; Inert atmosphere;
90%
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

4-chloro-phenol
106-48-9

4-chloro-phenol

1-bromo-4-(4-chlorophenoxy)-2-(trifluoromethyl)benzene
1417782-30-9

1-bromo-4-(4-chlorophenoxy)-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Stage #1: 4-chloro-phenol With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 120℃; for 1h; Inert atmosphere;
Stage #2: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene In 1-methyl-pyrrolidin-2-one at 140℃; for 5h; Inert atmosphere;
87.99%
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 5h;3.14 g
propan-1-ol
71-23-8

propan-1-ol

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

1-bromo-4-propoxy-2-(trifluoromethyl)benzene
1186482-11-0

1-bromo-4-propoxy-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With sodium hydride In mineral oil at 20 - 145℃; Microwave irradiation; Sealed tube;86%
Stage #1: propan-1-ol With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium tert-butylate In toluene at 50℃; for 0.5h; Inert atmosphere;
Stage #2: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene In toluene at 50℃; for 0.5h; Inert atmosphere;
Trimethyl borate
121-43-7

Trimethyl borate

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

(4-fluoro-2-(trifluoromethyl)phenyl)boronic acid

(4-fluoro-2-(trifluoromethyl)phenyl)boronic acid

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene With n-butyllithium In tetrahydrofuran; hexane at -30℃; Inert atmosphere; Flow reactor;
Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -30℃; Inert atmosphere; Flow reactor;
85%
pyrrolidin-3-ol
40499-83-0

pyrrolidin-3-ol

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-ol
1198181-18-8

1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-ol

Conditions
ConditionsYield
With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 85℃; for 16h; Inert atmosphere;84%
With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate In toluene at 85℃; for 16h; Inert atmosphere;84%
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

3-Formylphenylboronic acid
87199-16-4

3-Formylphenylboronic acid

C14H8F4O
955930-75-3

C14H8F4O

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 80℃; for 5h; Inert atmosphere;77%
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

C13H14BBrF4O2

C13H14BBrF4O2

Conditions
ConditionsYield
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Glovebox;71%
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Glovebox;71%
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide

N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide

4’-fluoro-N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-2’-(trifluoromethyl)biphenyl-4-sulfonamide

4’-fluoro-N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-2’-(trifluoromethyl)biphenyl-4-sulfonamide

Conditions
ConditionsYield
With dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium; sodium carbonate In 1,4-dioxane; water at 110℃; for 6h; Inert atmosphere;47%
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

1-[4'-fluoro-2'-(trifluoromethyl)-1,1'-biphenyl-3-yl]-5-methyl-1H-pyrazole-3-carboxamide

1-[4'-fluoro-2'-(trifluoromethyl)-1,1'-biphenyl-3-yl]-5-methyl-1H-pyrazole-3-carboxamide

Conditions
ConditionsYield
Stage #1: 1-(3-bromophenyl)-5-methyl-1H-pyrazole-3-carboxamide With 4,4,5,5-tetramethyl-2-(3,3,4,4-tetramethylborolan-1-yl)-1,3,2-dioxaborolane; potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In dimethyl sulfoxide at 140℃; for 0.333333h; Microwave irradiation;
Stage #2: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In water; dimethyl sulfoxide at 140℃; for 0.777778h; Microwave irradiation;
41%
formic acid
64-18-6

formic acid

1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-amine
1258861-52-7

1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-amine

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

[4-fluoro-2-(trifluoromethyl)phenyl]-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]-4-piperidyl]ammonium formate

[4-fluoro-2-(trifluoromethyl)phenyl]-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]-4-piperidyl]ammonium formate

Conditions
ConditionsYield
Stage #1: 1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-amine; 1-bromo-4-fluoro-2-(trifluoromethyl)benzene With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 110℃; Inert atmosphere;
Stage #2: formic acid In acetonitrile
13%
N-2-adamantyl-morpholine-2-carboxyamide hydrochloride

N-2-adamantyl-morpholine-2-carboxyamide hydrochloride

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

N-2-adamantyl-4-(4-fluoro-2-trifluorophenyl)morpholine-2-carboxyamide

N-2-adamantyl-4-(4-fluoro-2-trifluorophenyl)morpholine-2-carboxyamide

Conditions
ConditionsYield
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) In toluene at 100℃; for 5h;10%
4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride
652170-12-2

4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-trifluoromethylphenyl)piperidin-3-ol

4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-trifluoromethylphenyl)piperidin-3-ol

Conditions
ConditionsYield
With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) In toluene at 100℃; for 4h;
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

2-bromo-5-fluoro-1-nitro-3-trifluoromethyl-benzene
917391-24-3

2-bromo-5-fluoro-1-nitro-3-trifluoromethyl-benzene

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene With sulfuric acid; sulfur trioxide; potassium nitrate In dichloromethane at 20 - 30℃; for 25h;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water
2-hydroxyethyl acetate
542-59-6

2-hydroxyethyl acetate

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

2-[4-bromo-3-(trifluoromethyl)phenoxy]ethanol
955929-82-5

2-[4-bromo-3-(trifluoromethyl)phenoxy]ethanol

Conditions
ConditionsYield
Stage #1: 2-hydroxyethyl acetate With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene In N,N-dimethyl-formamide at 20℃; for 1.5h;
(2,3-dihydrobenzo[1,4]oxazin-4-yl)[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,5-dihydropyrrol-1-yl]methanone
1000689-11-1

(2,3-dihydrobenzo[1,4]oxazin-4-yl)[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,5-dihydropyrrol-1-yl]methanone

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

(2,3-dihydrobenzo[1,4]oxazin-4-yl)[3-(4-fluoro-2-(trifluoromethyl)phenyl)-2,5-dihydropyrrol-1-yl]methanone
1000689-12-2

(2,3-dihydrobenzo[1,4]oxazin-4-yl)[3-(4-fluoro-2-(trifluoromethyl)phenyl)-2,5-dihydropyrrol-1-yl]methanone

Conditions
ConditionsYield
With sodium carbonate In 1,2-dimethoxyethane; water for 14h; Heating / reflux;
2-hydroxyethyl acetate
542-59-6

2-hydroxyethyl acetate

1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

C11H10BrF3O3
955932-76-0

C11H10BrF3O3

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

({1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid
1198180-38-9

({1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 85 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 60 °C
2.2: 1 h / 60 °C
View Scheme
Multi-step reaction with 2 steps
1.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 16 h / 85 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / 60 °C
2.2: 1 h / 60 °C
View Scheme
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

4-pyridylboronic acid
1692-15-5

4-pyridylboronic acid

4-(4-fluoro-6-trifluoromethylphenyl)pyridine
1214345-41-1

4-(4-fluoro-6-trifluoromethylphenyl)pyridine

Conditions
ConditionsYield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 85℃; for 10h;
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

4-(4-fluoro-6-trifluoromethylphenyl)pyridine-N-oxide
1219454-46-2

4-(4-fluoro-6-trifluoromethylphenyl)pyridine-N-oxide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 10 h / 85 °C
2: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 °C
View Scheme
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

4-(4-fluoro-6-trifluoromethylphenyl)pyridine-2-carbonitrile
1219454-47-3

4-(4-fluoro-6-trifluoromethylphenyl)pyridine-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 10 h / 85 °C
2: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 °C
3: triethylamine / acetonitrile / 14 h / 90 °C
View Scheme
1-bromo-4-fluoro-2-(trifluoromethyl)benzene
40161-55-5

1-bromo-4-fluoro-2-(trifluoromethyl)benzene

4-(4-fluoro-6-trifluoromethylphenyl)pyridine-2-carboxamide oxime
1219454-48-4

4-(4-fluoro-6-trifluoromethylphenyl)pyridine-2-carboxamide oxime

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 10 h / 85 °C
2: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 °C
3: triethylamine / acetonitrile / 14 h / 90 °C
4: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 3 h / 20 °C
View Scheme

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