40167-20-2

Basic information

• Product Name: N-(METHYLTHIO)PHTHALIMIDE 97
• Synonyms: N-(METHYLTHIO)PHTHALIMIDE 97;N-(Methylthio)phthalimide;N-(METHYLTHIO)PHTHALIMIDE 97%
• CAS NO: 40167-20-2
• Molecular Formula: C₉H₇NO₂S
• Molecular Weight: 193.22238
• Mol File: 40167-20-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 176-180 °C(lit.)
• Appearance: /
• CAS DataBase Reference: N-(METHYLTHIO)PHTHALIMIDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: N-(METHYLTHIO)PHTHALIMIDE 97(40167-20-2)
• EPA Substance Registry System: N-(METHYLTHIO)PHTHALIMIDE 97(40167-20-2)

Safety Data

• Hazardous Substances Data: 40167-20-2(Hazardous Substances Data)

Usage

General Description

N-(Methylthio)phthalimide 97, also known as MTP, is a chemical compound used as a rubber vulcanization accelerator. It is a crystalline solid with a white to pale yellow color and is primarily used in the production of rubber products and tires to improve their mechanical properties. MTP functions by promoting the cross-linking of polymer chains in the rubber, ultimately increasing its strength, elasticity, and resistance to heat and aging. However, MTP should be handled with caution, as it can be irritating to the skin, eyes, and respiratory system, and may cause allergic reactions in some individuals. Overall, N-(Methylthio)phthalimide 97 is an important chemical in the rubber industry for improving the performance and durability of rubber products.

Upstream product

• 136918-14-4 phthalimide 
• 624-92-0 Dimethyldisulphide 
• 74-93-1 methylthiol 
• 1074-82-4 potassium phtalimide 
• 524-38-9 N-hydroxyphthalimide 

Downstream Products

• 108279-53-4 1-(methylthio)indole 
• 63056-18-8 methyl methanesulfenate 
• 108279-49-8 1-methylthiopyrrole 
• 84543-52-2 2-(methylthio)-1-phenyl-2-(phenylsulfonyl)ethan-1-one 
• 19916-62-2 2-(Methylsulfonyl)-2-(methylthio)-1-phenylethan-1-one 
• 141869-55-8 ethyl α,α-bis(methylthio)phenylacetate 
• 120816-06-0 17α-acetoxy-9α-fluoro-11β-hydroxy-16-β-methyl-21-methyldithio-1,4-pregnadiene-3,20-dione 
• 120816-09-3 9α-fluoro-11β-hydroxy-16β-methyl-21-methyldithio-17α-propanoyloxy-1,4-pregnadiene-3,20-dione 
• 119138-10-2 6α,9α-difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-21-methyldithio-1,4-pregnadiene-3,20-dione 
• 120816-13-9 17α-butanoyloxy-9α-fluoro-11β-hydroxy-16β-methyl-21-methyldithio-1,4-pregnadiene-3,20-dione 
• 120834-96-0 9α-fluoro-11β-hydroxy-16β-methyl-21-methyldithio-17α-(methylthio)acetoxy-1,4-pregnadiene-3,20-dione 
• 128292-32-0 9α-fluoro-11β-hydroxy-17α-(3-methoxycarbonyl)propanoyloxy-16β-methyl-21-methyldithio-1,4-pregnadiene-3,20-dione 
• 144303-79-7 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-methyldisulfanyl-1H-pyrimidin-2-one 
• 21504-18-7 2,2,2-Tris-methylsulfanyl-1-phenyl-ethanone 

Relevant articles and documents

Syntheses of carbocyclic uracil polyoxin C analogs: Application of Pd(0)/InI-allylation of 4-acetoxy-2-azetidinone

(Figure Presented) Carbocyclic uracil polyoxin C analogs are prepared from an acylnitroso-derived hetero Diels-Alder cycloadduct in fewer than nine steps. Pd(0)/InI-mediated allylation of 4-acetoxy-2-azetidinone is used to install the β-amino acid side ch

Allicin-inspired thiolated fluoroquinolones as antibacterials against ESKAPE pathogens

Thiolated fluoroquinolones were synthesized from ciprofloxacin and evaluated for antimicrobial activity against a panel of pathogenic bacteria. Gram-positive species including methicillin-resistant Staphylococcus aureus (MRSA) exhibited the highest level of increased sensitivity toward ciprofloxacin bound with a N-propylthio substituent. Evidence was found that the antibiotics form disulfides with low molecular weight thiols in bacteria and potentiate generation of cytosolic reactive oxygen species (ROS). In final analysis, the enhanced anti-MRSA activity of thiolated fluoroquinolones was attributed to increased cell permeability and reaction with cytosolic thiols that yields an inactive disulfide metabolite and the parent drug ciprofloxacin as an inhibitor of DNA synthesis.

Preparation of 2-(2-cyanoethyl)sulfanyl-1H-isoindole-1,3-(2H)-dione and related sulfur-transfer agents

The title compound 3 and 4-[(2-cyanoethyl)sulfanyl]morpholine-3,5-dione 12 are both conveniently prepared in good yield from 2-cyanoethyl disulfide, which itself is readily prepared in one step from S-(2-cyanoethyl)isothiouronium chloride 4. In the same way, dimethyl and diphenyl disulfides are converted, into 2-methylsulfanyl- and 2-phenylsulfanyl-1H-isoindole-1,3-(2H)-diones 8a and 8b, respectively, also in good yields.