4021-75-4Relevant articles and documents
COMPOUNDS USEFUL IN INHIBITING KETOHEXOKINASE AND METHODS OF MAKING AND USING THE SAME
-
Page/Page column 41, (2021/08/20)
The present invention relates to compounds that can act as inhibitors of ketohexokinase (KHK) and that can be useful in the treatment of diseases and/or disorders associated with KHK. In some embodiments, the present invention relates to compounds and com
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Futatsugi, Kentaro,Smith, Aaron C.,Tu, Meihua,Raymer, Brian,Ahn, Kay,Coffey, Steven B.,Dowling, Matthew S.,Fernando, Dilinie P.,Gutierrez, Jemy A.,Huard, Kim,Jasti, Jayasankar,Kalgutkar, Amit S.,Knafels, John D.,Pandit, Jayvardhan,Parris, Kevin D.,Perez, Sylvie,Pfefferkorn, Jeffrey A.,Price, David A.,Ryder, Tim,Shavnya, Andre,Stock, Ingrid A.,Tsai, Andy S.,Tesz, Gregory J.,Thuma, Benjamin A.,Weng, Yan,Wisniewska, Hanna M.,Xing, Gang,Zhou, Jun,Magee, Thomas V.
, p. 13546 - 13560 (2021/01/01)
Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resistance. Ketohexokinase (KHK) converts fructose to fructose-1
SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS
-
Paragraph 0274; 0275, (2017/07/14)
Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.