40371-61-7

Basic information

• Product Name: N-(3-Bromo-4-methylphenyl)acetamide
• Synonyms: 3'-Bromo-4'-methylacetanilide;N-(3-Bromo-4-methylphenyl)acetamide
• CAS NO: 40371-61-7
• Molecular Formula: C₉H₁₀BrNO
• Molecular Weight: 0
• Mol File: 40371-61-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-Bromo-4-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Bromo-4-methylphenyl)acetamide(40371-61-7)
• EPA Substance Registry System: N-(3-Bromo-4-methylphenyl)acetamide(40371-61-7)

Safety Data

• Hazardous Substances Data: 40371-61-7(Hazardous Substances Data)

Upstream product

• 7745-91-7 3-bromo-4-methylaniline 
• 108-24-7 acetic anhydride 
• 103-89-9 4-Methylacetanilide 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 10387-40-3 potassium thioacetate 
• 507-09-5 tiolacetic acid 
• 75-05-8 acetonitrile 

Downstream Products

• 55415-33-3 2-bromo-4-acetamidobenzoic acid 
• 40371-63-9 5-bromo-4-methyl-2-nitroaniline 
• 40371-62-8 acetic acid-(5-bromo-4-methyl-2-nitro-anilide) 
• 101251-11-0 3-bromo-N,4-dimethylbenzenamine 
• 13480-37-0 3-phenyl-4-methylaniline 
• 62827-39-8 3-Bromo-5-nitro-p-toluidine 
• 70733-25-4 3-Bromo-5-methyl-1,2-diaminobenzene 
• 2486-52-4 2-bromo-4-aminobenzoic acid 
• 1172115-34-2 C₁₅H₂₂BNO₃ 
• 872856-30-9 ethyl 2-(5-acetylamino-2-methylphenyl)-2-oxoacetate 
• 1338684-19-7 5-bromo-4-methyl-2-nitro-N-(3-phenylpropyl)aniline 
• 1338684-20-0 5-allyl-4-methyl-2-nitro-N-(3-phenylpropyl)aniline 
• 1338684-21-1 5-[(2E)-4-methoxybut-2-en-1-yl]-4-methyl-2-nitro-N-(3-phenylpropyl)aniline 
• 1338684-18-6 5-(4-methoxybutyl)-4-methyl-N-(3-phenylpropyl)benzene-1,2-diamine 

Relevant articles and documents

Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids

Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2?H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.

ONE-POT REDUCTIVE ACETAMIDATION OF ARYL NITRO COMPOUNDS

The present invention provides a method for the reductive acetamidation of an aryl nitro compound by reacting a substituted acid with an aryl nitro compound and adding a catalytic amount of a base with the substituted acid and the aryl nitro compound to form an acetamidation aryl nitro compound. The acetamidation aryl nitro compound is then purified.

One-step reductive amidation of nitro arenes: Application in the synthesis of Acetaminophen

A novel thioacetate mediated one-step reductive acetamidation of aryl nitro compounds was developed and applied to an efficient synthesis of acetaminophen. The reaction also proceeds well without a solvent in the presence of a catalytic amount of surfactant.