40438-48-0

Basic information

• Product Name: 2-(METHYLDIPHENYLSILYL)ETHANOL
• Synonyms: 2-(METHYLDIPHENYLSILYL)ETHANOL;(2-HYDROXYETHYL)DIPHENYMETHYLSILANE;2-(DIPHENYLMETHYLSILYL)ETHANOL;2-(methyldiphenylsilyl)-ethano;(2-hydroxyethyl)diphenylmethylsilane;Ethanol,2-(methyldiphenylsilyl)-;(2-Hydroxyethyl)diphenylmethylsilane, 2-(Diphenylmethylsilyl)ethanol
• CAS NO: 40438-48-0
• Molecular Formula: C₁₅H₁₈OSi
• Molecular Weight: 242.39
• EINECS: 254-919-9
• Mol File: 40438-48-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 152 °C0.2 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.063 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.49E-06mmHg at 25°C
• Refractive Index: n20/D 1.580(lit.)
• BRN: 4428743
• CAS DataBase Reference: 2-(METHYLDIPHENYLSILYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLDIPHENYLSILYL)ETHANOL(40438-48-0)
• EPA Substance Registry System: 2-(METHYLDIPHENYLSILYL)ETHANOL(40438-48-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 23-24/25
• WGK Germany: 3
• Hazardous Substances Data: 40438-48-0(Hazardous Substances Data)

Usage

Description

2-(METHYLDIPHENYLSILYL)ETHANOL, also known as 2-(Diphenylmethylsilyl)ethanol, is an organic compound with the chemical formula C14H16OSi. It is characterized by the presence of a methyldiphenylsilyl group attached to an ethanol molecule. 2-(METHYLDIPHENYLSILYL)ETHANOL is known for its unique chemical properties and potential applications in various fields.

Uses

Used in Chemical Synthesis:
2-(METHYLDIPHENYLSILYL)ETHANOL is used as a key intermediate in the preparation of 2-diphenylmethylsilylethyldithiophosphorodichloridate. 2-(METHYLDIPHENYLSILYL)ETHANOL is an important precursor in the synthesis of various organophosphorus compounds, which have applications in pharmaceuticals, agrochemicals, and other industries.

InChI:InChI=1/C15H18OSi/c1-17(13-12-16,14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,16H,12-13H2,1H3

Upstream product

• 77772-21-5 tert-butyl α-(methyldiphenylsilyl)acetate 
• 144-79-6 chloromethyldiphenylsilane 

Downstream Products

• 73364-60-0 Dithiophosphoric acid S,S'-bis-(4-methoxy-phenyl) ester O-[2-(methyl-diphenyl-silanyl)-ethyl] ester 
• 155398-45-1 (2-diphenylmethylsilylethoxy)bis(N,N-diisopropylamino)phosphine 
• 158817-18-6 bis<2-(methyldiphenylsilyl)ethyl> N,N-diisopropylphosphoramidite 
• 162554-42-9 bis<2-(methyldiphenylsilyl)ethyl> N,N-diethylphosphoramidite 
• 289698-26-6 C₁₅H₁₇Cl₂OPSi 
• 887620-15-7 2-(methyldiphenylsilyl)ethyl chloroformate 
• 887620-19-1 formic acid [bis(N,N-diisopropylamino)phosphino]-β-(diphenylmethylsilyl)ethyl ester 
• 887620-20-4 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-2'-deoxythymidine 
• 887620-21-5 3'-O-(N,N-diisopropylamino)phosphinoformic acid β-(diphenylmethylsilyl)ethyl ester 5'-O-di-p-anisylphenylmethyl-N4-(9-fluorenylmethyloxycarbonyl)-2'-deoxycytidine 
• 887620-31-7 C₆₃H₇₅N₄O₁₅PSi₂ 
• 288089-41-8 Phosphoric acid bis-((S)-2,3-dihydroxy-propyl) ester 2-(methyl-diphenyl-silanyl)-ethyl ester 
• 288089-40-7 Phosphoric acid bis-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl) ester 2-(methyl-diphenyl-silanyl)-ethyl ester 
• 288089-42-9 phosphoric acid bis-[3-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-propyl] ester 2-(methyl-diphenyl-silanyl)-ethyl ester 

Relevant articles and documents

Synthesis and Application of Bis-Silylethyl-Derived Phosphate-Protected Fmoc-Phosphotyrosine Derivatives for Peptide Synthesis

Three Fmoc-phosphotyrosine derivatives with silylethyl-based phosphate protection were synthesized and evaluated for use in peptide synthesis.The stability of these derivatives toward piperidine/DMF (1:4) treatment and their cleavability with TFA solutions were examined.On the basis of these data, the bis-protected Fmoc-phosphotyrosine derivative or Fmoc-Tyr(PO3MDPSE2)-OH, was shown to be the most suitable candidate for the production of phosphotyrosine peptides.The syntheses of phosphotyrosine peptides including one containing Met and Cys are described.