405066-12-8

Basic information

• Product Name: 3-Piperidinemethanol, 1-[[1-(4-chlorophenyl)cyclobutyl]carbonyl]-,methanesulfonate (ester)
• CAS NO: 405066-12-8
• Molecular Formula: C18H24ClNO4S
• Molecular Weight: 385.912
• Mol File: 405066-12-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Piperidinemethanol, 1-[[1-(4-chlorophenyl)cyclobutyl]carbonyl]-,methanesulfonate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidinemethanol, 1-[[1-(4-chlorophenyl)cyclobutyl]carbonyl]-,methanesulfonate (ester)(405066-12-8)
• EPA Substance Registry System: 3-Piperidinemethanol, 1-[[1-(4-chlorophenyl)cyclobutyl]carbonyl]-,methanesulfonate (ester)(405066-12-8)

Safety Data

• Hazardous Substances Data: 405066-12-8(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 404886-44-8 [3-(Benzo[1,3]dioxol-5-yloxymethyl)-piperidin-1-yl]-[1-(4-chloro-phenyl)-cyclobutyl]-methanone 
• 4606-65-9 3-(hydroxymethy)piperidine 
• 50921-39-6 1-(4-chlorophenyl)cyclobutane-1-carboxylic acid 

Downstream Products

• 454445-16-0 [1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-trifluoromethoxy-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone 
• 454445-17-1 [1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-isopropoxy-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone 
• 454445-14-8 [1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone 
• 454445-15-9 [1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-fluoro-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone 
• 454445-18-2 [1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-hydroxy-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone 
• 404887-33-8 [1-(4-Chloro-phenyl)-cyclobutyl]-[3(4-trifluoromethyl-phenylsulfanylmethyl)-piperidin-1-yl]-methanone 
• 405090-61-1 (3-Azidomethyl-piperidin-1-yl)-[1-(4-chloro-phenyl)-cyclobutyl]-methanone 
• 404886-44-8 [3-(Benzo[1,3]dioxol-5-yloxymethyl)-piperidin-1-yl]-[1-(4-chloro-phenyl)-cyclobutyl]-methanone 

Relevant articles and documents

Method of treating addiction or dependence using a ligand for a monoamine receptor or transporter

One aspect of the present invention relates to a method of treating of drug addiction or drug dependence in a mammal, comprising the step of administering to a mammal in need thereof a therapuetically effective amount of a heterocyclic compound, e.g., a 3-substituted piperidine. In a preferred embodiment, the method of the present invention treats cocaine addiction or methamphetamine addiction.

Piperidine-piperazine ligands for neurotransmitter receptors

One aspect of the present invention relates to piperidine-piperazine compounds. A second aspect of the present invention relates to the use of the piperidine-piperazine compounds as ligands for various mammalian cellular receptors or transporters or both,