40550-12-7

Basic information

• Product Name: 2-chloro-N,N,N',N'-tetramethylpropane-1,3-diamine
• Synonyms: 2-chloro-N,N,N',N'-tetramethylpropane-1,3-diamine;2-Chloro-N,N,N',N'-tetramethyl-1,3-propanediamine
• CAS NO: 40550-12-7
• Molecular Formula: C₇H₁₇ClN₂
• Molecular Weight: 164.67628
• EINECS: 254-969-1
• Mol File: 40550-12-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 124.6°Cat760mmHg
• Flash Point: 29.1°C
• Appearance: /
• Density: 0.966g/cm³
• CAS DataBase Reference: 2-chloro-N,N,N',N'-tetramethylpropane-1,3-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N,N,N',N'-tetramethylpropane-1,3-diamine(40550-12-7)
• EPA Substance Registry System: 2-chloro-N,N,N',N'-tetramethylpropane-1,3-diamine(40550-12-7)

Safety Data

• Hazardous Substances Data: 40550-12-7(Hazardous Substances Data)

Upstream product

• 5966-51-8 1,3-bis-(dimethylamino)propan-2-ol 

Downstream Products

• 58-37-7 Proquamezin 
• 102322-18-9 tetra-N-methyl-2-phenothiazin-10-yl-propanediyldiamine 
• 113183-81-6 N²-(4-methoxy-benzyl)-N¹,N¹,N³,N³-tetramethyl-N²-phenyl-propane-1,2,3-triyltriamine 
• 25827-24-1 C₁₉H₂₇N₃OS 
• 96111-17-0 1-(4-butoxy-phenoxy)-2,3-bis-dimethylamino-propane 
• 122984-57-0 hydrochloric acid salt of 1,3-bis(dimethylamino)-2-propyl-4-chlorophenoxyacetate 

Relevant articles and documents

Benzo[A] [phenazin-11-carboxamide derivatives and their use as joint inhibitors of topomerase I and II

A compound which is a benzo[a]phenazine-11-carboxamide derivative of formula (I) wherein each of R1 to R4, which are the same or different, is selected from hydrogen, halogen, hydroxyl, C1-C6 alkoxy which is unsubstituted or substituted, heteroaryloxy, C1-C6 alkyl which is unsubstituted or substituted, nitro, cyano, azido, amidoxime, CO2R10, CON(R12)2, OCON(R12), SR10, SOR11, SO2(R11), SO2N(R12)2, N(R12)2, NR10SO2R11, N(SO2R11)2NR10(CH2)nCN, NR10COR11, OCOR11 or COR10; each of R5 to R7, which are the same or different, is selected from hydrogen, halogen, hydroxy, C1-C6 alkoxy, C1-C6 alkyl, SR10 and N(R12)2; Q is C1-C6 alkylene which is unsubstituted or substituted by (i) C1-C6 alkyl which is unsubstituted or substituted, (ii) hydroxy, provided that the hydroxy group is not, to either of the N atoms adjacent to Q in formula (I), (iii) CO2R10, or (iv) CON(R12); R1 and R9, which are the same or different, are each hydrogen or C1-C6 alkyl, or R8 and R9 together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered N-containing heterocyclic ring which may include one additional heteroatom selected from O, N and S, or one of R8 and R9 is an alkylene chain optionally interrupted by O, N or S, which is attached to a carbon atom on the alkylene chain represented by Q to complete a saturated 5- or 6-membered N-containing heterocyclic ring as defined above; or a pharmaceutically acceptable salt thereof; with the proviso that at least one R1 to R4 is other than hydrogen. These compounds are inhibitors of topoisomerase I and/or topoisomerase II and can be used to treat tumours, including tumours which express MDR.

SYNTHESES OF AMINOTHIOL DERIVATIVES.

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