58-37-7

Basic information

• Product Name: Aminopromazine
• Synonyms: aminopromazine;Proquamezine;N,N,N',N'-Tetramethyl-3-(10H-phenothiazin-10-yl)-1,2-propanediamine;[1-(dimethylaminomethyl)-2-phenothiazin-10-yl-ethyl]-dimethyl-amine;1-N,1-N,2-N,2-N-tetramethyl-3-phenothiazin-10-ylpropane-1,2-diamine;N1,N1,N2,N2-tetramethyl-3-phenothiazin-10-yl-propane-1,2-diamine
• CAS NO: 58-37-7
• Molecular Formula: C₁₉H₂₅N₃S
• Molecular Weight: 327.49
• EINECS: 200-378-9
• Mol File: 58-37-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 443.671 °C at 760 mmHg
• Flash Point: 222.124 °C
• Appearance: /
• Density: 1.123 g/cm³
• Vapor Pressure: 4.55E-08mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: Aminopromazine(CAS DataBase Reference)
• NIST Chemistry Reference: Aminopromazine(58-37-7)
• EPA Substance Registry System: Aminopromazine(58-37-7)

Safety Data

• Hazardous Substances Data: 58-37-7(Hazardous Substances Data)

Usage

Therapeutic Function

Spasmolytic

InChI:InChI=1/C19H25N3S/c1-20(2)13-15(21(3)4)14-22-16-9-5-7-11-18(16)23-19-12-8-6-10-17(19)22/h5-12,15H,13-14H2,1-4H3

Upstream product

• 92-84-2 10H-phenothiazine 
• 40550-12-7 1,3-bis(dimethylamino)-2-chloropropane 

Relevant articles and documents

Phenothiazinealkaneamines for treatment of neurotoxic injury

Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows such conditions as stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a phenothiazinealkaneamine compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula STR1 wherein each of R1 and R2 is hydrido; wherein each of R3 and R4 is independently selected from hydrido, methyl and ethyl; wherein each of R5 and R6 is independently selected from methyl, ethyl and n-propyl; wherein X is sulfur; wherein m is zero; and wherein n is two.