405516-88-3Relevant articles and documents
Enantioselective Synthesis of Silacyclopentanes
Igawa, Kazunobu,Yoshihiro, Daisuke,Abe, Yusuke,Tomooka, Katsuhiko
, p. 5814 - 5818 (2016)
A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β-eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β-elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.