40570-19-2

Basic information

• Product Name: 2-(1-carboxyethyl)benzoic acid
• Synonyms: 2-(1-carboxyethyl)benzoic acid
• CAS NO: 40570-19-2
• Molecular Weight: 194.187
• Mol File: 40570-19-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(1-carboxyethyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-carboxyethyl)benzoic acid(40570-19-2)
• EPA Substance Registry System: 2-(1-carboxyethyl)benzoic acid(40570-19-2)

Safety Data

• Hazardous Substances Data: 40570-19-2(Hazardous Substances Data)

Upstream product

• 89-51-0 Homophthalic acid 
• 3759-28-2 (2-cyanophenyl)acetonitrile 
• 716-43-8 dimethyl homophthalate 
• 7647-01-0 hydrogenchloride 
• 104292-98-0 methyl 2-(1-methoxy-1-oxopropan-2-yl)benzoate 
• 6072-57-7 3-methylindanone 

Downstream Products

• 1269514-77-3 2-benzyloxy-4-methylisoquinoline-1,3(2H,4H)-dione 

Relevant articles and documents

2-Hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: Influence of the alkylation of position 4

We report herein the synthesis of a series of fifteen 2- hydroxyisoquinoline-1,3(2H,4H)-dione derivatives. Alkyl and arylalkyl groups were introduced on position 4 of the basis scaffold. All the compounds presented poor inhibitory properties against HIV-1 reverse transcriptase ribonuclease H (RNase H). Four compounds inhibited HIV-1 integrase at a low micromolar level. A docking study using the later crystallographic data available for PFV integrase allowed us to explain the slightly improved integrase inhibitory activities of 4-pentyl and 4-(3-phenylpropyl)-2-hydroxyisoquinoline-1,3(2H,4H)-diones, when compared to the basis scaffold. Physicochemical studies were consistent with 1:1 and 1:2 (metal/ligand) stoichiometries of the magnesium complexes in solution. Unfortunately all tested compounds exhibited high cellular cytotoxicity in cell culture which limited their applications as antiviral agents. However these identified integrase inhibitors provide a very good basis for the development of new hits.

Facile and Efficient Syntheses of Carboxylic Anhydrides and Amides Using (Trimethylsilyl)ethoxyacetylene

(Trimethylsilyl)ethoxyacetylene, a stable and easy-handling reagent, serves as an excellent dehydrating agent for the synthesis of carboxylic anhydrides and amides from the corresponding carboxylic acids.By means of this reagent, various types of acid-sensitive carboxylic anhydrides and amides were obtained almost in quantative yields.Twenty-two examples of carboxylic anhydrides and 12 examples of amides were presented.