406196-67-6Relevant articles and documents
Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra series
Angibaud, Patrick,Mevellec, Laurence,Meyer, Christophe,Bourdrez, Xavier,Lezouret, Patricia,Pilatte, Isabelle,Poncelet, Virginie,Roux, Bruno,Merillon, Sophie,End, David W.,Van Dun, Jacky,Wouters, Walter,Venet, Marc
, p. 702 - 714 (2008/02/11)
Based on the structure of R115777 (tipifarnib, Zarnestra), a series of farnesyltransferase inhibitors have been synthesized by modification of the 2-quinolinone motif and transposition of the 4-chlorophenyl ring to the imidazole or its replacem