406939-93-3 Usage
Description
1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylmethyl]-benzyl-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone is a complex organic compound with multiple trifluoroacetyl groups attached to a tetraazacyclotetradecane core. This molecule is derived from 1,4,8,11-tetraazacyclotetradecane Hexa(Trifluoroacetic Acid Salt) (T283955) and is used as a protected form of Plerixafor, a drug with various applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylmethyl]-benzyl-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone is used as a protected form of Plerixafor for the preparation of Plerixafor derivatives. Plerixafor is a drug that modulates the CXCR4 receptor, which plays a role in various biological processes, including cell migration and cancer progression. The protection of Plerixafor with multiple trifluoroacetyl groups allows for its stabilization and controlled release in pharmaceutical applications.
Used in Research and Development:
In the field of research and development, this compound serves as an important intermediate for the synthesis of various Plerixafor-related compounds. Its unique structure and functional groups make it a valuable tool for exploring new drug candidates and understanding the mechanisms of action of Plerixafor and its derivatives.
Used in Drug Delivery Systems:
Similar to Gallotannin, this compound can potentially be incorporated into drug delivery systems to improve its bioavailability and therapeutic outcomes. The use of nanoparticles or other carriers could enhance the delivery of Plerixafor and its derivatives to specific target cells or tissues, increasing their efficacy and reducing potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 406939-93-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,6,9,3 and 9 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 406939-93:
(8*4)+(7*0)+(6*6)+(5*9)+(4*3)+(3*9)+(2*9)+(1*3)=173
173 % 10 = 3
So 406939-93-3 is a valid CAS Registry Number.
406939-93-3Relevant articles and documents
Dendrimers based on a bis-cyclam core as fluorescence sensors for metal ions
Bergamini, Giacomo,Ceroni, Paola,Balzani, Vincenzo,Cornelissen, Leandra,Van Heyst, Jeroen,Lee, Sang-Kyu,Voegtle, Fritz
, p. 2959 - 2964 (2005)
We have synthesized a novel dendrimer (1) based on two covalently linked cyclam units as a core appended to six branches, each one consisting of one dimethoxybenzene and two naphthyl units (cyclam = 1,4,8,11- tetraazacyclotetradecane). Such a dendrimer shows three fluorescence bands which can be assigned to naphthyl localized excited states (λmax = 336 nm), naphthyl excimers (λmax ca. 390 nm), and naphthyl-amine exciplexes (λmax = 510 nm). Protonation or complexation of the bis-cyclam core with Zn2+ does not affect the absorption spectrum of the dendrimer, but causes noticeable changes in the fluorescence intensity of the three component bands. Complexation with Cu 2+ not only causes changes in the relative intensities of the fluorescence bands, but also the appearance of a new absorption band in the near UV spectral region. Analysis of the titration curves has allowed us to obtain clear evidence for the formation of 1 : 1 (1(H+), [Zn(1)] 2+, [Cu(1)]2+) and 2 : 1 (1(2H+), [Zn 2(1)]4+, [Cu2(1)]4+) species. Comparison with the behaviour of a previously investigated parent monocyclam dendrimer (2) suggests that in the 1 : 1 species of 1 both the cyclam units are involved in the complexation with Zn2+ and Cu2+. The Royal Society of Chemistry 2005.
64Cu-AMD3100-A novel imaging agent for targeting chemokine receptor CXCR4
Jacobson, Orit,Weiss, Ido D.,Szajek, Lawrence,Farber, Joshua M.,Kiesewetter, Dale O.
experimental part, p. 1486 - 1493 (2009/09/25)
CXCR4 is a chemokine receptor which has been shown to be exploited by various tumors for increased survival, invasion, and homing to target organs. We developed a one step radiosynthesis for labeling the CXCR4-specific antagonist AMD3100 with Cu-64 to pro
