407-95-4Relevant articles and documents
Ionic liquids as media for nucleophilic flurination
Murray, Christopher B.,Sandford, Graham,Korn, Stewart R.
, p. 81 - 84 (2007/10/03)
The use of Room Temperature Ionic Liquids (RTILs) for a variety of halogen exchange (Halex) fluorination processes using alkali metal fluorides is assessed. Whilst fluorination of a range of halogenated substrates is possible in good yield, the utility of RTILs as reusable, inert media for such reactions is limited by the gradual decomposition of the RTIL in the presence of highly basic fluoride ion.
A useful conversion of alcohols to alkyl fluorides
Flosser, David A,Olofson, Roy A
, p. 4275 - 4279 (2007/10/03)
A useful conversion of alcohols to alkyl fluorides via their fluoroformates is introduced. The fluoroformates are obtained in nearly quantitative yield from the alcohols by treatment with COF2 (generated in situ from bis(trichloromethyl) carbonate) in ether with KF as an added acid scavenger. The neat fluoroformates are cleaved to the fluorides by heating at 120-125°C using hexabutylguanidinium fluoride (HBGF) as the catalyst.
Activation of tetrabutylammonium hydrogen difluoride with pyridine: A mild and efficient procedure for nucleophilic fluorination
Moughamir, Khadija,Atmani, Aziz,Mestdagh, Helene,Rolando, Christian,Francesch, Charlette
, p. 7305 - 7306 (2007/10/03)
The nucleophilic fluorination of alkyl iodides, bromides and tosylates and of α-bromo- or α-chloroketones is smoothly effected by tetrabutylammonium hydrogen difluoride in the presence of pyridine, in dioxane or THF, with good or satisfying substitution-to-elimination ratio.