40808-21-7

Basic information

• Product Name: 5-(4-METHYLPHENYL)-2-THIOPHENECARBOXYLIC ACID
• Synonyms: 5-(4-METHYLPHENYL)-2-THIOPHENECARBOXYLIC ACID;AKOS BAR-1206;5-P-TOLYLTHIOPHENE-2-CARBOXYLIC ACID
• CAS NO: 40808-21-7
• Molecular Formula: C₁₂H₁₀O₂S
• Molecular Weight: 218.27
• Mol File: 40808-21-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-METHYLPHENYL)-2-THIOPHENECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-METHYLPHENYL)-2-THIOPHENECARBOXYLIC ACID(40808-21-7)
• EPA Substance Registry System: 5-(4-METHYLPHENYL)-2-THIOPHENECARBOXYLIC ACID(40808-21-7)

Safety Data

• Hazardous Substances Data: 40808-21-7(Hazardous Substances Data)

Upstream product

• 51335-91-2 1-[5-(4-methylphenyl)thiophene-2-yl]ethanone 
• 38401-68-2 5-(4-methylphenyl)thiophene-2-carbaldehyde 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 5720-05-8 4-methylphenylboronic acid 
• 16939-04-1 2-p-tolylthiophene 
• 108-88-3 toluene 
• 38425-26-2 4-chloro-1-(4-methylphenyl)butan-1-one 
• 62224-19-5 5-bromo-2-thiophenecarboxylic acid methyl ester 
• 50971-49-8 5-(4-methylphenyl)thiophene-2-carboxylic acid methyl ester 

Downstream Products

• 61100-11-6 ethyl 5-(p-tolyl) thiophene-2-carboxylate 
• 845753-53-9 2-bromo-5-(4-methylphenyl)thiophene 

Relevant articles and documents

Hedgehog signal pathway inhibitor

The invention provides a Hedgehog signal pathway inhibitor as well as stereoisomers, tautomers, hydrates, solvates or pharmaceutically acceptable salts thereof, and the structural formula of the inhibitor is as shown in a formula (I). The invention further provides a preparation method and application of a compound. The compound provided by the invention is novel in structure; a signal transduction pathway adjusted by Hedgehog protein, Ptch, Gli and/or Smo can be adjusted through the compound of the formula I.

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.