408497-91-6 Usage
General Description
Formamide, N-[5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2-(phenylmethoxy)phenyl]- is a complex chemical compound with a long and specific molecular structure. It contains several functional groups including an amine, hydroxyl, and phenyl groups, which contribute to its potential biological activity and pharmacological characteristics. The compound may have potential applications in the pharmaceutical industry due to its molecular structure, which could potentially interact with biological systems in a specific and targeted manner. Further research and analysis would be required to fully understand the properties and potential uses of this chemical compound.
Check Digit Verification of cas no
The CAS Registry Mumber 408497-91-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,8,4,9 and 7 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 408497-91:
(8*4)+(7*0)+(6*8)+(5*4)+(4*9)+(3*7)+(2*9)+(1*1)=176
176 % 10 = 6
So 408497-91-6 is a valid CAS Registry Number.
408497-91-6Relevant articles and documents
An efficient enantioselective synthesis of (R,R)-formoterol, a potent bronchodilator, using lipases
Campos, Francisco,Bosch, M. Pilar,Guerrero, Angel
, p. 2705 - 2717 (2007/10/03)
The potent β2-adrenergic receptor agonist formoterol (R,R)-1 has been obtained in enantiomerically pure form by a convenient chemoenzymatic approach by coupling of epoxide (R)-6 with the unprotected primary amine (R)-9. Both chiral precursors have been prepared by enantiodifferentiation processes involving Pseudomonas cepacia (lipase PS) and Candida antarctica lipase (CALB), respectively. For the resolution of amine 9, we have found that utilization of triethylamine as non-reactive base enhances the reaction rate and the enantioselectivity of the process. The key coupling reaction of (R)-6 and (R)-9 has been conducted through derivatization of the amine with the labile trimethylsilyl group, which liberates the amino group of the resulting amino alcohol (R,R)-11 upon column chromatography purification. In this way, the overall approach is shorter than others previously described. Copyright (C) 2000 Elsevier Science Ltd.