41037-29-0

Basic information

• Product Name: 6-CHLOROLEPIDINE
• Synonyms: 6-Chloro-4-methylquinoline
• CAS NO: 41037-29-0
• Molecular Formula: C₁₀H₈ClN
• Molecular Weight: 177.63
• Mol File: 41037-29-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 65-66.5 °C
• Boiling Point: 294.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.225±0.06 g/cm3(Predicted)
• PKA: 4.85±0.16(Predicted)
• CAS DataBase Reference: 6-CHLOROLEPIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLOROLEPIDINE(41037-29-0)
• EPA Substance Registry System: 6-CHLOROLEPIDINE(41037-29-0)

Safety Data

• Hazardous Substances Data: 41037-29-0(Hazardous Substances Data)

Usage

General Description

6-Chlorolepidine is a chemical compound with the molecular formula C11H10ClN. It is a chlorinated derivative of lepidine and is widely used as an intermediate in the synthesis of pharmaceutical drugs and agrochemicals. 6-Chlorolepidine is a yellow to brown crystalline powder and is soluble in organic solvents like ethanol and acetone. It is also used as a building block in the synthesis of various heterocyclic compounds, such as pyridine derivatives. Additionally, 6-Chlorolepidine is a versatile starting material for the preparation of various biologically active molecules and plays a crucial role in the development of new therapeutic agents.

Upstream product

• 6607-66-5 1,3,3-trimethoxybutane 
• 20265-96-7 p-chloroaniline hydrochloride 
• 6322-49-2 4-chloro-2-butanone 
• 106-47-8 4-chloro-aniline 
• 78-94-4 methyl vinyl ketone 
• 18826-95-4 1.3-butanediol 
• 4203-18-3 4,6-dichloroquinoline 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 4594-87-0 6-chloro-4-styryl-quinoline 
• 109809-90-7 4-[trans-2-(6-chloro-[4]quinolyl)-vinyl]-N,N-dimethyl-aniline 
• 482583-75-5 6-chloroquinoline-4-carboxaldehyde 
• 62482-29-5 6-chloroquinoline-4-carboxylic acid 

Relevant articles and documents

Metal-Free Chemoselective Oxidation of 4-Methylquinolines into Quinoline-4-Carbaldehydes

A convenient protocol for the synthesis of quinoline-4-carbaldehydes via chemoselective oxidation of 4-methylquinolines using hypervalent iodine(III) reagents as oxidant is described. This method highlights metal-free and mild reaction conditions, nice yield, good functional group tolerance, and high chemoselectivity.

Quinolines synthesis by reacting 1,3-butanediol with anilines in the presence of iron catalysts

2-, 4-, 6-, 7-, and 8-substituted quinolines were synthesized in 78–95% yield by the reaction of 1,3- butanediol with anilines in the presence of iron catalysts in carbon tetrachloride.

Efficient microwave-assisted synthesis of quinolines and dihydroquinolines under solvent-free conditions

A convenient and efficient procedure for the synthesis of quinolines and dihydroquinolines has been developed by a simple one-pot reaction of anilines with alkyl vinyl ketones on the surface of silica gel impregnated with indium(III) chloride under microwave irradiation without any solvent.