41125-09-1

Basic information

• Product Name: 3-oxo-butyraldehyde; sodium enolate
• CAS NO: 41125-09-1
• Molecular Weight: 108.072
• Mol File: 41125-09-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 3-oxo-butyraldehyde; sodium enolate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-oxo-butyraldehyde; sodium enolate(41125-09-1)
• EPA Substance Registry System: 3-oxo-butyraldehyde; sodium enolate(41125-09-1)

Safety Data

• Hazardous Substances Data: 41125-09-1(Hazardous Substances Data)

Upstream product

• 107-31-3 Methyl formate 
• 67-64-1 acetone 
• 201230-82-2 carbon monoxide 
• 124-41-4 sodium methylate 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 39745-39-6 6-methyl-3-nitrohydropyridin-2-one 
• 65169-38-2 2-chloro-4-methyl-3-pyridinecarbonitrile 
• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 4652-27-1 4-methoxy-3-buten-2-one 
• 4241-27-4 1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile 
• 59951-32-5 (Z)-4-(cyclohexylamino)but-3-en-2-one 
• 92676-71-6 (Z)-4-(allylamino)but-3-en-2-one 
• 92676-72-7 cis-1-isopropylamino-1-buten-3-one 
• 56570-43-5 (Z)-4-(benzylamino)-but-3-en-2-one 
• 76946-78-6 (3E)-4-[methyl(phenyl)amino]but-3-en-2-one 
• 15295-33-7 (3Z)-4-[(4-nitrophenyl)amino]but-3-en-2-one 
• 54920-45-5 p-Methylphenylamino-4-buten-3-on-2 
• 60390-89-8 (3Z)-4-(phenylamino)but-3-en-2-one 
• 6051-55-4 (3E)-4-morpholinyl-3-buten-2-one 

Relevant articles and documents

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

Zeste enhancer homolog 2 (EZH2) is highly expressed in various malignant tumors, which could silence tumor suppressor genes via trimethylation of H3K27. Herein was first reported a novel series of pyrrole-3-carboxamide derivatives carrying a pyridone fragment as EZH2 inhibitors. By combining computational modeling, in vitro cellular assays and further rational structure-activity relationship exploration and optimization, compound DM-01 showed powerful inhibition towards EZH2. DM-01 was found to have significant ability to reduce the cellular H3K27me3 level in K562 cells in the Western blot test. Meanwhile, our data showed that knockdown EZH2 in A549 cells resulted in a decrease of cell sensitivity to DM-01 at 50 and 100 μM. DM-01 could also increase the transcription expression of DIRAS3 in a dose-dependent manner, a tumor suppressor in the downstream of EZH2, suggesting it was worth investigating further as a lead compound.

Compound preparation method

The invention relates to a compound preparation method. Organic solvents and sodium methylate are added into a reaction vessel, carbon monoxide is led into the reaction vessel to perform reaction, acetone and organic solvent mixed solution is dropped after reaction to continue reaction to generate an intermediate sodium salt as shown in a formula I, the intermediate sodium salt reacts with dimethylamine to generate 4-N, N-dimethyl butene-3-ketone as shown in a formula II. Synthesis steps can be finished in one vessel, and the compound preparation method is low in cost and suitable for industrialization production.

MANUFACTURE OF HYDRAZINYL COMPOUNDS USEFUL IN THE MANUFACTURE OF PYRAZOLE CARBOXYLIC ACID AND DERIVATIVES, HYDRAZINYL COMPOUNDS AND THEIR USE

The present invention concerns the manufacture of hydrazinyl compounds useful in the manufacture of pyrazole carboxylic acid and derivatives thereof and processes for the manufacture of agrochemical or pharmaceutical compounds. The invention also concerns hydrazinyl compounds and their use.