4241-27-4 Usage
Description
3-Cyano-6-methyl-2(1H)-pyridinone is a slightly yellow granular crystalline powder that is a key reactant in the synthesis of various pharmaceutical compounds. It is known for its role in creating supramolecular structures of coordination copper(I) compounds, showcasing its significance in chemical research and development.
Uses
Used in Pharmaceutical Synthesis:
3-Cyano-6-methyl-2(1H)-pyridinone is used as a reactant for the synthesis of Milrinone (M344680), a selective phosphodiesterase inhibitor. 3-Cyano-6-methyl-2(1H)-pyridinone exhibits vasodilating and positive inotropic activity, making it valuable in the treatment of certain cardiovascular conditions.
Additionally, 3-Cyano-6-methyl-2(1H)-pyridinone is used in the preparation of N3?-pyridyl thiamine, a potent in vitro thiamine antagonist. This application highlights its importance in the development of therapeutic agents targeting thiamine-related conditions.
Used in Chemical Research:
3-Cyano-6-methyl-2(1H)-pyridinone is also utilized in the investigation of supramolecular structures of coordination copper(I) compounds. This research area is crucial for understanding the properties and potential applications of these complex structures in various fields, including materials science and catalysis.
Check Digit Verification of cas no
The CAS Registry Mumber 4241-27-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,4 and 1 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4241-27:
(6*4)+(5*2)+(4*4)+(3*1)+(2*2)+(1*7)=64
64 % 10 = 4
So 4241-27-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2O/c1-9-4-2-3-6(5-8)7(9)10/h2-4H,1H3
4241-27-4Relevant articles and documents
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Binovi,Arlt
, p. 1656 (1961)
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Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents
Zhou, Qifan,Jia, Lina,Du, Fangyu,Dong, Xiaoyu,Sun, Wanyu,Wang, Lihui,Chen, Guoliang
supporting information, p. 2247 - 2255 (2020/02/20)
Zeste enhancer homolog 2 (EZH2) is highly expressed in various malignant tumors, which could silence tumor suppressor genes via trimethylation of H3K27. Herein was first reported a novel series of pyrrole-3-carboxamide derivatives carrying a pyridone fragment as EZH2 inhibitors. By combining computational modeling, in vitro cellular assays and further rational structure-activity relationship exploration and optimization, compound DM-01 showed powerful inhibition towards EZH2. DM-01 was found to have significant ability to reduce the cellular H3K27me3 level in K562 cells in the Western blot test. Meanwhile, our data showed that knockdown EZH2 in A549 cells resulted in a decrease of cell sensitivity to DM-01 at 50 and 100 μM. DM-01 could also increase the transcription expression of DIRAS3 in a dose-dependent manner, a tumor suppressor in the downstream of EZH2, suggesting it was worth investigating further as a lead compound.
CONDENSED AZAHETEROARYL COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY AGAINST TUBERCULOSIS BACTERIA
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Page/Page column 32, (2020/01/08)
Present invention relates to novel compound of general formula (I), their enantiomers, their diastereomers, their pharmaceutically accepted salts, or pro-drugs thereof, which are useful for the treatment of bacterial infection. The compounds of general formula (I) exhibit DprE1 enzyme inhibitory activity.