28900-10-9 Usage
Description
2-Chloro-6-methyl-3-pyridinecarbonitrile, also known as 2-chloro-6-methylnicotinonitrile, is an organic compound characterized by its light yellow to brown crystalline flake or needle-like appearance. It serves as a crucial building block in the synthesis of various biologically active compounds, making it a valuable component in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
2-Chloro-6-methyl-3-pyridinecarbonitrile is used as a synthetic building block for the preparation of biologically active compounds. It plays a significant role in the development of new potent anticancer agents, such as 2-(Alkoxycarbonyl)-3-Anilinobenzo[b]thiophenes and Thieno[2,3-b]pyridines. These compounds have shown potential in combating cancer by targeting specific cellular pathways and mechanisms.
Additionally, 2-Chloro-6-methyl-3-pyridinecarbonitrile may be used in the preparation of methyl-2-nitropyridinecarboxamides, which are also of interest in the pharmaceutical industry due to their potential applications in drug development.
Used in Chemical Industry:
In the chemical industry, 2-Chloro-6-methyl-3-pyridinecarbonitrile is utilized as an intermediate in the synthesis of various organic compounds. Its unique structure and functional groups make it a versatile building block for creating a wide range of products, from pharmaceuticals to specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 28900-10-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,9,0 and 0 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 28900-10:
(7*2)+(6*8)+(5*9)+(4*0)+(3*0)+(2*1)+(1*0)=109
109 % 10 = 9
So 28900-10-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H5ClN2/c1-5-2-3-6(4-9)7(8)10-5/h2-3H,1H3
28900-10-9Relevant articles and documents
Novel 3-pyridinecarbonitriles incorporating sulfonamide moieties as anti-breast cancer agents
Ghorab, Mostafa M.,Alsaid, Mansour S.
, p. 441 - 448 (2016)
A novel series of 3-pyridinecarbonitrile derivatives incorporating sulfonamide moieties and sulfonyl derivatives was synthesized using 2-chloro-6-methylnicotinonitrile as a strategic starting material. The structures of the synthesized compounds were eluc
KINASE INHIBITOR
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Paragraph 0149; 0150; 0151; 0152, (2017/06/21)
[Problem] To provide a novel PIM-3 inhibitor and a novel cancer therapeutic drug, in particular, a therapeutic drug for pancreatic cancer. [Solution] A PIM-3 kinase inhibitor comprising a compound represented by general formula (I) or a pharmacologically acceptable salt, hydrate or solvate thereof.
Synthesis of methyl 3-azidothieno[2,3-b]pyridine-2-carboxylates and application of the huisgen reaction
Chaouni, Wafaa,Aadil, Mina,Djellal, Ahmed,Kirsch, Gilbert
, p. 509 - 518 (2014/06/10)
The preparation of new substituted methyl 3-azidothieno[2,3-b]pyridine carboxylates by azotization of methyl 3-aminothieno[2,3-b]pyridine and subsequent treatment with sodium azide is described. Via Huisgen's 1,3-dipolar cycloaddition between substituted alkynes and the prepared azides, methyl 1,2,3-triazolo-thieno[2,3-b]pyridine carboxylates have been obtained.
