82756-10-3

Basic information

• Product Name: 3-Pyridinecarbonitrile, 6-methyl-2-[(4-methylphenyl)amino]-
• CAS NO: 82756-10-3
• Molecular Formula: C14H13N3
• Molecular Weight: 223.277
• Mol File: 82756-10-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarbonitrile, 6-methyl-2-[(4-methylphenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile, 6-methyl-2-[(4-methylphenyl)amino]-(82756-10-3)
• EPA Substance Registry System: 3-Pyridinecarbonitrile, 6-methyl-2-[(4-methylphenyl)amino]-(82756-10-3)

Safety Data

• Hazardous Substances Data: 82756-10-3(Hazardous Substances Data)

Upstream product

• 28900-10-9 2-chloro-6-methylnicotinonitrile 
• 106-49-0 p-toluidine 

Downstream Products

• 95848-01-4 N-(3-Cyano-6-methyl-pyridin-2-yl)-N-p-tolyl-acetamide 
• 95848-11-6 2-acetonyl-7-methyl-1-(p-tolyl)-1,4-dihydro-4-oxopyrido<2,3-d>pyrimidine 
• 95848-06-9 2,7-Dimethyl-1-p-tolyl-1H-pyrido[2,3-d]pyrimidin-4-one 

Relevant articles and documents

Reactions of 6-Methyl- and 4,6-Dimethyl-2-arylaminonicotinonitriles with Acids

A substituted nicotinic acid is formed when 6-methyl-2-anilinonicotinonitrile is refluxed with concentrated hydrochloric acid, whereas 4,6-dimethyl-2-anilinonicotinonitrile is not hydrolyzed under these and more severe conditions because of steric hindrance.Both of these nitriles undergo cyclization to 10-aminobenzo-1,8-naphthyridine derivatives under the influence of concentrated sulfuric acid.When 6-methyl-2-arylaminonicotinonitriles are heated in polyphosphoric acid (PPA), they are converted to 2-arylaminonicotinic acid amides and, in part, to benzo-1,8-naphthyrid-10-one derivatives, while 4,6-dimethyl-2-arylaminonicotinonitriles are converted primarily to 10-aminobenzo-1,8-naphthyridines.