4125-95-5

Basic information

• Product Name: DL-N-Methylleucine
• Synonyms: DL-N-Methylleucine
• CAS NO: 4125-95-5
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.2
• Mol File: 4125-95-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DL-N-Methylleucine(CAS DataBase Reference)
• NIST Chemistry Reference: DL-N-Methylleucine(4125-95-5)
• EPA Substance Registry System: DL-N-Methylleucine(4125-95-5)

Safety Data

• Hazardous Substances Data: 4125-95-5(Hazardous Substances Data)

Upstream product

• 74-89-5 methylamine 
• 163887-30-7 N-Z-N-Me-(S,R)-Ile 
• 61548-98-9 C₉H₉NO₂C₂H₃CHC 
• 3160-59-6 N-benzyloxycarbonyl-isoleucine 
• 66866-65-7 3-benzyloxycarbonyl-4-(2-methylpropyl)oxazolidin-5-one 
• 319-78-8 isoleucine 
• 865-47-4 potassium tert-butylate 
• 74-88-4 methyl iodide 
• 3160-59-6 N-benzyloxycarbonyl-L-isoleucine 

Relevant articles and documents

Iheyamides A-C, Antitrypanosomal Linear Peptides Isolated from a Marine Dapis sp. Cyanobacterium

Iheyamides A (1), B (2), and C (3), new linear peptides, were isolated from a marine Dapis sp. cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Iheyamide A (1) showed moderate antitrypanosomal activities against Trypanosoma brucei rhodesiense and Trypanosoma brucei brucei (IC50 = 1.5 μM), but the other two analogues, iheyamides B (2) and C (3), did not (IC50 > 20 μM, respectively). The structure-activity relationship clarified that an isopropyl-O-Me-pyrrolinone moiety was necessary for the antitrypanosomal activity. Furthermore, the cytotoxicity of 1 against normal human cells, WI-38, was 10 times weaker than its antitrypanosomal activity (IC50 = 18 μM).

Preparation of N-Z-protected N-methylated amino acids

A process for preparing N-protected N-alkylated amino acids of the formula I: in which the substituents have the meanings stated in the description, comprises mixing a compound of the formula II with a solution of potassium tert-butanolate in a non-protic organic solvent, and subsequently adding a C1-2-alkyl halide.

A practical approach for the optically pure N-Methyl-α- amino acids

A new practical synthesis of N-Methyl-α-amino acids by racemization free methodology has been developed. The method involves the reductive cleavage of N-protected oxazotidinones using hydrogen in the presence of Pd/C to give the title compounds in quantitative yields.