41252-79-3

Basic information

• Product Name: 2-CHLORO-2-(4-CHLORO-PHENYL)-ETHANOL
• Synonyms: 2-CHLORO-2-(4-CHLORO-PHENYL)-ETHANOL;Benzeneethanol, .beta.,4-dichloro-
• CAS NO: 41252-79-3
• Molecular Formula: C₈H₈Cl₂O
• Molecular Weight: 191.05
• Mol File: 41252-79-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 286.5 °C at 760 mmHg
• Flash Point: 119.9 °C
• Appearance: /
• Density: 1.328 g/cm³
• Vapor Pressure: 0.00123mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 2-CHLORO-2-(4-CHLORO-PHENYL)-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-2-(4-CHLORO-PHENYL)-ETHANOL(41252-79-3)
• EPA Substance Registry System: 2-CHLORO-2-(4-CHLORO-PHENYL)-ETHANOL(41252-79-3)

Safety Data

• Hazardous Substances Data: 41252-79-3(Hazardous Substances Data)

Usage

General Description

2-CHLORO-2-(4-CHLORO-PHENYL)-ETHANOL is a chemical compound that falls under the category of organochlorine compounds. It is a colorless to pale yellow liquid with a molecular formula of C8H8Cl2O. 2-CHLORO-2-(4-CHLORO-PHENYL)-ETHANOL is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also utilized in the production of pesticides, fungicides, and herbicides. Additionally, it can be employed as a solvent or intermediate in chemical reactions. However, it is important to handle this compound with caution as it is toxic to aquatic organisms and may cause skin and eye irritation in humans.

InChI:InChI=1/C8H8Cl2O/c9-7-3-1-6(2-4-7)8(10)5-11/h1-4,8,11H,5H2

Upstream product

• 2788-86-5 4-Chlorostyrene oxide 
• 104-88-1 4-chlorobenzaldehyde 
• 7477-64-7 1-(p-chlorophenyl)-1,2-ethanediol 
• 7138-34-3 p-chloromandelic acid 

Downstream Products

• 58369-61-2 2-chloro-2-(4-chlorophenyl)acetaldehyde 
• 10465-91-5 3-(4-chlorophenyl)-2H-chromen-2-one 

Relevant articles and documents

Selective monochlorination of unsymmetrical vicinal diols with chlorinated iminium chlorides

Chlorinated iminium chlorides have been identified to promote the highly efficient and selective mono-chlorination of unsymmetrical vicinal diols. Vilsmeier reagent, namely, (chloromethylene)dimethyliminium chloride, enables highly reactive and regioselective chlorination of 1,2- and 1,3-diols featured one secondary benzylic hydroxy group and one primary aliphatic hydroxy group to give the corresponding 1,2- and 1,3-chlorohydrins. Viehe's salts (α,α-dichloro iminium salts) exhibit excellent reactivity and good selectivity for vicinal diols to give the corresponding chlorohydrin carbamates via a cyclic intermediate in situ. The chlorination protocols tolerate diverse functional groups, including halogens, naphthalene rings, nitro, and cyano. Moreover, the optical purity of chiral diols could be retained during this chlorination reaction.

Facile and regioselective conversion of epoxides into β-chlorohydrins using ZrCl4

Epoxides were efficiently converted into the corresponding β-chlorohydrins in good yields by treatment with ZrCl4 in acetonitrile.