414910-27-3 Usage
Description
Casopitant, a selective neurokinin-1 (NK-1) receptor antagonist, is a pharmaceutical compound that has demonstrated potential in various therapeutic applications. It works by blocking the action of substance P, a neurotransmitter involved in pain transmission, inflammation, and mood regulation.
Uses
Used in Pharmaceutical Industry:
Casopitant is used as an antidepressant for the treatment of unipolar depression, addressing the underlying neurochemical imbalances and improving mood and emotional well-being.
Casopitant is used as an anxiolytic for the management of anxiety disorders, helping to alleviate the symptoms of anxiety by modulating the neurotransmitter systems involved in stress response.
Casopitant is used as a sleep aid for the treatment of insomnia disorders, promoting restful sleep by targeting the neurotransmitters responsible for sleep regulation.
Casopitant is used as an antiemetic for the prevention and treatment of nausea and vomiting, particularly in patients undergoing chemotherapy or other treatments that may cause these side effects.
Used in Gastroenterology:
Casopitant is used as a therapeutic agent for the treatment of functional dyspepsia, a chronic disorder characterized by persistent upper abdominal pain or discomfort, by reducing the sensitivity of the gut to various stimuli.
Casopitant is used as a treatment for irritable bowel syndrome (IBS), a common gastrointestinal disorder marked by abdominal pain, bloating, and changes in bowel habits, by targeting the neurotransmitter systems involved in gut motility and visceral hypersensitivity.
Casopitant is used as a treatment for gastroesophageal reflux disease (GERD), a condition where stomach acid frequently flows back into the esophagus, causing heartburn and other symptoms, by reducing the frequency and severity of acid reflux episodes.
Used in Urology:
Casopitant is used as a treatment for overactive bladder disease, a condition characterized by urinary urgency, frequency, and incontinence, by modulating the neurotransmitter systems that control bladder function and reducing involuntary muscle contractions.
Check Digit Verification of cas no
The CAS Registry Mumber 414910-27-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,1,4,9,1 and 0 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 414910-27:
(8*4)+(7*1)+(6*4)+(5*9)+(4*1)+(3*0)+(2*2)+(1*7)=123
123 % 10 = 3
So 414910-27-3 is a valid CAS Registry Number.
414910-27-3Relevant articles and documents
Application of the QbD principles in the development of the casopitant mesylate manufacturing process. Process research studies for the definition of the control strategy of some drug substance-CQAs for stages 2a, 2b, and 2c
Cimarosti, Zadeo,Bravo, Fernando,Castoldi, Damiano,Tinazzi, Francesco,Provera, Stefano,Perboni, Alcide,Papini, Damiano,Westerduin, Pieter
experimental part, p. 805 - 814 (2011/03/23)
Casopitant was identified as a potent NK1 antagonist by GlaxoSmithKline (GSK). It was selected as part of a wide drug discovery programme within GSK for its potential activities on a number of therapeutic targets such as inflammatory bowel dise
Chemical compounds
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Page/Page column 13, (2010/02/05)
Formula (1) wherein R represents a halogen atom or a C1-4 alkyl group; R1 represents a C1-4 alkyl group; R2 represents hydrogen or a C1-4 alkyl group; R3 represents hydrogen, or a C1-4 alkyl group; R4 represents a trifluorometyl group; R5 represents hydrogen, a C1-4 alkyl group or C(0)R6; R6? represents C1-4 alkyl, C3-7 cycloalkyl, NH(C1-4 alkyl) or N(C1-4alkyl)2; m is zero or an integer from 1 to 3; n is an integer from 1 to 3 and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation and their use in the treatment of conditions mediated bytachykinins.
