41575-66-0

Basic information

• Product Name: platinum(2+) dichloride - N,N-dimethylethane-1,2-diamine (1:1)
• CAS NO: 41575-66-0
• Molecular Formula: C₄H₁₂Cl₂N₂Pt
• Molecular Weight: 354.1415
• Mol File: 41575-66-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 93.5°C at 760 mmHg
• Flash Point: 23.9°C
• Vapor Pressure: 49.3mmHg at 25°C
• CAS DataBase Reference: platinum(2+) dichloride - N,N-dimethylethane-1,2-diamine (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: platinum(2+) dichloride - N,N-dimethylethane-1,2-diamine (1:1)(41575-66-0)
• EPA Substance Registry System: platinum(2+) dichloride - N,N-dimethylethane-1,2-diamine (1:1)(41575-66-0)

Safety Data

• Hazardous Substances Data: 41575-66-0(Hazardous Substances Data)

Upstream product

• 104034-36-8 cis-(N,N-dimethyl-ethylenediamine)diiodoplatinum(II) 
• 7647-14-5 sodium chloride 
• 10025-99-7 potassium tetrachloroplatinate(II) 
• 108-00-9 N,N-dimethylethylenediamine 
• 102-54-5 ferrocene 
• 144754-55-2 platinum(IV)Cl₄(a-dmen) 
• 7732-18-5 water 

Downstream Products

• 14024-97-6 trans-dichlorobis(pyridine)platinum(II) 
• 127471-93-6 b-chloro-c(N),d(N')-{N,N-dimethyl-N'-pentafluorophenylethane-1,2-diaminato^(1-)}-a-pyridineplatinum(II) 
• 124-38-9 carbon dioxide 
• 117533-81-0 b-chloro-c(N),d(N')-{N,N-dimethyl-N'-(2,3,5,6-tetrafluoro-4-methylphenyl)ethane-1,2-diaminato^(1-)}-a-pyridineplatinum(II) 
• 55172-29-7 thallium chloride 
• 127419-28-7 b-chloro-c(N),d(N')-{N,N-dimethyl-N'-(2,3,5,6-tetrafluorophenyl)ethane-1,2-diaminato^(1-)}-a-pyridineplatinum(II) 
• 72151-35-0 trans-[platinum(II) dichloride bis(4-picoline)] 
• 117533-76-3 b-chloro-c(N),d(N')-{N,N-dimethyl-N'-(2,3,5,6-tetrafluorophenyl)ethane-1,2-diaminato^(1-)}-a-(4-methylpyridine)platinum(II) 
• 117533-75-2 b-chloro-c(N),d(N')-{N,N-dimethyl-N'-(2,3,5,6-tetrafluorophenyl)ethane-1,2-diaminato^(1-)}-a-(2-methylpyridine)platinum(II) 
• 120128-05-4 b-chloro-c(N),d(N')-{N,N-dimethyl-N'-(2,3,5,6-tetrafluorophenyl)ethane-1,2-diaminato^(1-)}-a-triphenylphosphineplatinum(II) 

Relevant articles and documents

Reaction of chlorine with platinum(IV) triamine containing N,N-dimethylethylenediamine. the crystal structure of [Pt{(CH3) 2N(CH2)2NH2}PyCl3] Cl·H2O[Pt{(CH3)2N(CH2) 2NCl}PyCl3], and [Pt{(CH3)2N(CH 2)2NH2...

Full title: Reaction of chlorine with platinum(IV) triamine containing N,N-dimethylethylenediamine. the crystal structure of [Pt{(CH3) 2N(CH2)2NH2}PyCl3] Cl·H2O[Pt{(CH3)2N(CH2) 2NCl}PyCl3], and [Pt{(CH3)2N(CH 2)2NH2}PyCl4]. The Platinum(II) diamine with N,N-dimethylethylenediamine (N,N-dimeEn) [Pt{(CH3)2N(CH2)2NH 2}Cl2] (I) was synthesized. The reaction of the diamine with pyridine gave Pt(II) tetramine [Pt{(CH3)2N(CH 2)2NH2}Py2]Cl2 (II), which was oxidized with chlorine to give Pt(IV) triamine Pt{[(CH 3)2N(CH2)2}PyCl3]Cl ? H2O (III). The reaction of III with chlorine (chloroamidation) yielded chloroimide [Pt{(CH3)2N(CH2) 2NCl}PyCl3] (IV). The IR spectra of complexes I-IV and UV/Vis spectra of III and IV were studied. X-Ray diffraction analysis was performed for III (monoclinic crystals, space group P21/c, a = 7.7437(6), b = 8.1100(7), c = 28.52992(2) A?, β = 93.7280(10)°, Z = 4, R hkl = 0.0420) and IV (orthorhombic crystals, space group Pna21, a = 15.7825(12), b = 7.4447(6), c = 12.3099(6) A?, Z = 4, R hkl = 0.0539). During oxidation of Pt(II) tetramine with chlorine, the pyridine molecule is removed from the cis position relative to the (CH 3)2N group (trans position relative to the NH2 group) of N,N-dimethylethylenediamine. The reaction of chloroimide complex IV with concentrated HCl (dechloroamidation) at 20°C afforded the initial complex III; that at 100°C, gave triamine III together with Pt(IV) diamine [Pt(N,N-dimeEn)Cl4] (V) (monoclinic crystals, space group P2 1/n, a = 7.1278(5), b = 11.5384(8), c = 12.7501(9) A?, β = 93.23(10)°, Z = 4, R hkl = 0.0239).

Trend in cytotoxic activity of a series of cis-[APtCl2] (A = ethylenediamine methylated at different positions) complexes

The study of a series of cis-[APtCl2] complexes (A = ethylenediamine, en, methylated at different positions) was carried out to evaluate the effect of different methyl substitutions on the cytotoxic properties of the resulting derivatives. As expected, differentially methylated complexes were found to differ widely in their cytotoxic effects on human cultured ovarian carcinoma cells (A2780). Molecular mechanics (MM) calculations have been performed to assess the relationship between differential diamine methylation and the repulsive energy of the corresponding complexes when interacting with DNA. Compounds that bind DNA at high energetic cost relative to cisplatin, due to the steric hindrance of additional methyl groups, have shown high values for IC50 (concentration inhibiting tumour cell growth by 50%). Semi-quantitative analyses with a DNA electrochemical biosensor confirm that the interaction between cis-[APtCl2] complexes and ds-DNA deposed onto the electrode is stronger for the non-methylated derivative with respect to the fully methylated congener. In addition, MM calculations were used to investigate the interactions between DNA and cis-[(P-L-A)PtCl2] complexes [A = en group linked to an antiestrogen-like pharmacophore, P, via a -(CH2)n- spacer (n = 2, 4, 6, 8 and 10), L].

Atom-transfer and outer-sphere reductions of platinum(IV) complexes. A comparative kinetic investigation

Reductions of platinum(IV) complexes of the type (N-N=en, meen, dmen, tmen, 1,2-pn, 1,3-pn) by FeCp2, Bu4NI and (ClO4)2 in the presence of Et4NCl have been kinetically investigated in methanol solution.The reactions with FeCp2 or Bu4NI obey e second-order rate law reductant), whereas the rate law for the reactions with (ClO4)2 in the presence of Et4NCl is: rate = Pt(II)+kPt(II)->2+4>.The reactivity of the complexes is enhanced by an increased steric hindrance of the N-N ligand.Such a reactivity trend is likely to be related to a parallel increased thermodynamic tendency of platinum(IV) towards reduction.The effect of steric hindrance on the rate is less pronounced in the reaction with 2+ probably due to a direct interaction between the N-N and the NH2Et ligands in the activated complex