4160-65-0

Basic information

• Product Name: (4-BroMophenyl)(thiophen-2-yl)Methanone
• Synonyms: (4-BroMophenyl)(thiophen-2-yl)Methanone;(4-bromophenyl)-2-thienylmethanone
• CAS NO: 4160-65-0
• Molecular Formula: C₁₁H₇BrOS
• Molecular Weight: 267.14168
• Mol File: 4160-65-0.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-BroMophenyl)(thiophen-2-yl)Methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BroMophenyl)(thiophen-2-yl)Methanone(4160-65-0)
• EPA Substance Registry System: (4-BroMophenyl)(thiophen-2-yl)Methanone(4160-65-0)

Safety Data

• Hazardous Substances Data: 4160-65-0(Hazardous Substances Data)

Usage

General Description

The chemical compound "(4-Bromophenyl)(thiophen-2-yl)methanone" is a synthetic compound made up of a bromophenyl group (containing a bromine atom attached to a phenyl ring) and a thiophen-2-yl group (a sulfur-containing five-membered aromatic ring) linked by a methanone group (a carbonyl connected to a methyl group). (4-BroMophenyl)(thiophen-2-yl)Methanone has not been extensively studied, hence detailed information regarding its physical and chemical properties, reactivity, toxicity, and potential applications is limited or not currently available. As with all chemicals, it should be handled, stored and disposed of in accordance with appropriate safety practices and regulations.

Upstream product

• 188290-36-0 thiophene 
• 586-75-4 4-chlorobenzoyl chloride 
• 586-76-5 4-Bromobenzoic acid 
• 40310-36-9 2-[α-(4-bromophenyl)-α-hydroxymethyl]thiophene 
• 2786-07-4 2-thienyl lithium 
• 192436-83-2 4-bromo-N-methoxy-N-methylbenzamide 
• 3437-95-4 2-Iodothiophene 
• 201230-82-2 carbon monoxide 
• 5467-74-3 4-Bromophenylboronic acid 
• 623-00-7 4-bromobenzenecarbonitrile 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 589-87-7 1,4-bromoiodobenzene 
• 74-86-2 acetylene 
• 112375-37-8 p-bromobenzoyl trifluoromethanesulfonate 

Downstream Products

• 25706-30-3 2-(4-Aminobenzoyl)thiophene 
• 79204-44-7 (thiophen-3-yl)(4-vinylphenyl)methanone 
• 698356-02-4 3-[4-(thiophene-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide 
• 929643-04-9 1-methyl-5-[4-(thien-2-yl-carbonyl)phenyl]-1H-pyrrole-2-carbonitrile 
• 1604048-08-9 (4-bromophenyl)(5-(2-nitrophenyl)thiophen-2-yl)methanone 

Relevant articles and documents

Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance

Microtubule targeting agents (MTAs) are among the most successful chemotherapeutic drugs, but their efficacy is often limited by the development of multidrug resistance (MDR). Therefore, the development of novel MTAs with the ability to overcome MDR is urgently needed. In this contribution, through modification of the unsymmetric biaryl compounds, we discovered a novel compound dxy-1-175 with potent anti-proliferative activity against cancer cells. Mechanistic study revealed that dxy-1-175 inhibited tubulin polymerization by interacting with the colchicine-binding site of tubulin, which caused cell cycle arrest at G2/M phase. Based on the predicted binding model of dxy-1-175 with tubulin, a series of new 4-benzoylbiphenyl analogues were designed and synthesized. Among them, the hydrochloride compound 12e with improved solubility and good stability in human liver microsome, exhibited the most potent anti-proliferative activity with IC50 value in the low nanomolar range, and markedly inhibited the growth of breast cancer 4T1 xenograft in vivo. Notably, 12e effectively overcame P-gp-mediated MDR and our preliminary data suggested that 12e may not be a substrate of P-glycoprotein (P-gp). Taken together, our study reveals a novel MTA 12e targeting the colchicine-binding site with potent anticancer activity and the ability to circumvent MDR.

Mitochondrial targeting fluorescent probe as well as synthesis method and application thereof

The invention relates to a mitochondrial targeting fluorescent probe as well as a synthesis method and application thereof. The mitochondrial targeting fluorescent probe (TPP-TPEDCH) is synthesized through a chemical reaction by taking a fluorescent molec

Decarboxylation with Carbon Monoxide: The Direct Conversion of Carboxylic Acids into Potent Acid Triflate Electrophiles

We report a new strategy for the conversion of carboxylic acids into potent acid triflate electrophiles. The reaction involves oxidative carbonylation of carboxylic acids with I2 in the presence of AgOTf, and is postulated to proceed via acyl hypoiodites that react with CO to form acid triflates. Coupling this chemistry with subsequent trapping with arenes offers a mild, room temperature approach to generate ketones directly from broadly available carboxylic acids without the use of corrosive and reactive Lewis or Bronsted acid additives, and instead from compounds that are readily available, stable, and functional group compatible.