417715-54-9

Basic information

• Product Name: 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid (4-nitro-phenyl)-amide
• Synonyms: 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid (4-nitro-phenyl)-amide
• CAS NO: 417715-54-9
• Molecular Weight: 495.269
• Mol File: 417715-54-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid (4-nitro-phenyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid (4-nitro-phenyl)-amide(417715-54-9)
• EPA Substance Registry System: 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid (4-nitro-phenyl)-amide(417715-54-9)

Safety Data

• Hazardous Substances Data: 417715-54-9(Hazardous Substances Data)

Upstream product

• 417715-45-8 N-propyl-2-(2-bromoethyl)amino benzoic amide 
• 118-92-3 anthranilic acid 
• 56814-10-9 2-amino-N-propylbenzamide 
• 118-48-9 isatoic anhydride 
• 100-28-7 4-Nitrophenyl isocyanate 
• 404958-71-0 1-(2-bromoethyl)-3-propyl-2,3-dihydro-1,2,3-benzodiazaphosphorin-4(1H)-one 2-oxide 

Relevant articles and documents

Efficient synthesis and crystal structure of 2-propyl-5-(substituted)phenyl-1,4-dioxo-1,2,3,4,5,6,7,8-octahydro-[1,4,2]diazap hosphorino[1,2-a][1,3,2]benzodiazaphosphorine 3-oxides

In order to search for novel antitumor and antiviral agents with high activity and low toxicity, some 2-propyl-5-(substituted)phenyl-1,4-dioxo-1,2,3,4,5,6,7,8-octahydro-[1,4,2]diazap hosphorino[1,2-a][1,3,2]benzodiazaphosphorine 3-oxides (2a-e) have been designed incorporating the proximate carbonyl and phosphoryl groups into the benzoannulated phosphadiamide heterocycle and synthesized in acceptable yields. These compounds contain the proximate carbonyl and phosphoryl groups in the fused heterocycle. Their structures were confirmed by spectroscopic methods and microanalyses. The results from X-ray crystallography analysis of 2a showed that the proximate carbonyl and phosphoryl groups are not coplanar because of their being jointly located in the fused heterocycle, having ring tension, and this then destroys the conjugation between the C=O and the P=O moieties. As a result, the length of the P-C bonds measured as 1.851(3)-1.852(3) A are just the same as that of a P-C bond not involved in conjugation (1.80-1.85 A). Also, the C(1), C(2), C(3), N(2), N(3), and P(1) atoms of the [1,4,2]diazaphosphorino moiety exist preferably in the boat conformation. The coplanar C(1), C(3), N(2), and N(3) atoms, within an average deviation of 0.0102, A, form the ground floor of the boat conformation, whereas the P(1) and C(2) atoms are on the same side of the coplanar structure with the distance of 0.7067 and 0.6315 A, respectively.