56814-10-9

Basic information

• Product Name: 2-AMINO-N-PROPYL-BENZAMIDE
• Synonyms: 2-AMINO-N-PROPYL-BENZAMIDE;AKOS BBB/075;benzamide, 2-amino-N-propyl-
• CAS NO: 56814-10-9
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23
• Mol File: 56814-10-9.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 363.7 °C at 760 mmHg
• Flash Point: 173.8 °C
• Appearance: /
• Density: 1.079g/cm³
• Vapor Pressure: 1.77E-05mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: 2-AMINO-N-PROPYL-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-PROPYL-BENZAMIDE(56814-10-9)
• EPA Substance Registry System: 2-AMINO-N-PROPYL-BENZAMIDE(56814-10-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 56814-10-9(Hazardous Substances Data)

Usage

General Description

2-Amino-N-propyl-benzamide is a chemical compound consisting of a benzene ring with an attached amide group and a propylamine side chain. It is often used in pharmaceutical research as a starting material for the synthesis of potential drug candidates. The compound is known to exhibit analgesic and anti-inflammatory properties, making it a potential candidate for the development of new pain-relief medications. It may also have potential applications in the treatment of neurodegenerative disorders and psychiatric conditions. However, further research and testing are required to fully understand its pharmacological properties and potential therapeutic uses.

InChI:InChI=1/C10H14N2O/c1-2-7-12-10(13)8-5-3-4-6-9(8)11/h3-6H,2,7,11H2,1H3,(H,12,13)

Upstream product

• 107-10-8 propylamine 
• 118-48-9 isatoic anhydride 
• 118-92-3 anthranilic acid 
• 91-56-5 indole-2,3-dione 
• 1022964-01-7 2-(propylcarbamoyl-phenyl)-carbamic acid tert-butyl ester 
• 68790-38-5 2-(tert-butyloxycarbonylamino)benzoic acid 
• 21563-73-5 2-aminobenzoyl chloride 
• 5344-90-1 2-Aminobenzyl alcohol 

Downstream Products

• 417715-45-8 N-propyl-2-(2-bromoethyl)amino benzoic amide 
• 417715-41-4 N-propyl-2-(2-hydroxyethyl)aminobenzoic amide 
• 417715-48-1 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid phenylamide 
• 417715-52-7 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid p-tolylamide 
• 417715-50-5 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid (4-chloro-phenyl)-amide 
• 417715-54-9 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid (4-nitro-phenyl)-amide 
• 815654-41-2 4-oxo-4-{{2-[(propylamino)carbonyl]phenyl}amino}butanoic acid 
• 1158553-50-4 2-oxo-2-{{2-[(propylamino)carbonyl]phenyl}amino}acetic acid 
• 1022964-12-0 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-propyl-benzamide 
• 1022964-04-0 2-(2,5-dichloro-pyrimidin-4-ylamino)-N-propyl-benzamide 
• 1385790-22-6 2-((1-acetyl-3-hydroxy-2-oxoindolin-3-yl)amino)-N-(n-propyl)benzamide 
• 26060-02-6 2-phenyl-3-n-propylquinazoline-4(3H)-one 
• 63586-34-5 3‐propyl‐2‐thioxo‐2,3‐dihydroquinazolin‐4(1H)‐one 
• 1486520-91-5 C₁₇H₁₉N₃O 

Relevant articles and documents

Efficient synthesis of 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives catalyzed by functionalized nanoporous silica

An efficient and facile method has been developed for the synthesis of various 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives, via a three-component reaction of 2-amino-N-(R)-benzamide derivatives with 2-formylbenzoic acid using sulfonic acid functionalized nanoporous silica as an efficient catalyst in ethanol under reflux. High yield of the desired products, reusability of the catalyst, and effortless workup step without using chromatography are the advantages of this method. Graphic abstract: [Figure not available: see fulltext.]

Design, synthesis, in vitro and in silico biological assays of new quinazolinone-2-thio-metronidazole derivatives

A new series of quinazolinone-2-thio-metronidazole derivatives 9a-o was designed, synthesized and assayed for their activities against metabolic enzymes human carbonic anhydrase I and II (hCAs I and II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glucosidase. The results indicated that all the synthesized compounds exhibited excellent inhibitory activities against mentioned enzymes as compared with standard inhibitors. Representatively, the most potent compound against CA enzymes, 4-fluorophenyl derivative 9i, was 4 and 7-times more potent than standard inhibitor acetazolamide against hCA I and II, respectively; 4-fluorobenzyl derivative 9m as the most potent compound against cholinesterase enzymes, was around 11 and 21-times more potent than standard inhibitor tacrine against AChE and BChE, respectively; the most active α-glucosidase inhibitor 9h with 4-methoxyphenyl moiety was 5-times more active that acarbose as standard inhibitor. Furthermore, in order to study interaction modes of the most potent compounds in the active site of their related enzymes, molecular modeling was performed. Druglikeness, ADME, and toxicity profile of the compounds 9i, 9m, and 9h were also predicted.

Synthesis of 2-aryl quinazolinones: Via iron-catalyzed cross-dehydrogenative coupling (CDC) between N-H and C-H bonds

Herein, we describe the direct synthesis of quinazolinones via cross-dehydrogenative coupling between methyl arenes and anthranilamides. The C-H functionalization of the benzylic sp3 carbon is achieved by di-t-butyl peroxide under air, and the subsequent amination-aerobic oxidation process completes the annulation process. Iron catalyzed the whole reaction process and various kinds of functional groups were tolerated under the reaction conditions, providing 31 examples of 2-aryl quinazolinones using methyl arene derivatives in yields of 57-95percent. The synthetic potential has been demonstrated by the additional synthesis of aryl-containing heterocycles. This journal is