41807-35-6

Basic information

• Product Name: 2,4-Imidazolidinedione, 5-phenyl-, (5R)-
• CAS NO: 41807-35-6
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Mol File: 41807-35-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4-Imidazolidinedione, 5-phenyl-, (5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Imidazolidinedione, 5-phenyl-, (5R)-(41807-35-6)
• EPA Substance Registry System: 2,4-Imidazolidinedione, 5-phenyl-, (5R)-(41807-35-6)

Safety Data

• Hazardous Substances Data: 41807-35-6(Hazardous Substances Data)

Usage

General Description

2,4-Imidazolidinedione, 5-phenyl-, (5R)- is a chemical compound with the molecular formula C9H8N2O2. It is an optically active form of the 2,4-Imidazolidinedione molecule, characterized by its specific stereochemistry. 2,4-Imidazolidinedione, 5-phenyl-, (5R)- is a white solid at room temperature and is commonly used in organic synthesis and pharmaceutical research. It is known for its role as a chiral building block in the preparation of various pharmaceutical and biologically active molecules. Additionally, it has potential applications in the development of new drugs and other biologically active compounds. Due to its unique properties, 2,4-Imidazolidinedione, 5-phenyl-, (5R)- is of interest to researchers in the fields of chemistry, pharmacology, and drug development.

Upstream product

• 27534-88-9 (5S)-5-phenyl-2,4-imidazolinedione 
• 6489-76-5 D-(-)-N-carbamoyl phenyl glycine 
• 590-28-3 potassium cyanate 
• 875-74-1 (R)-phenylglycine 

Relevant articles and documents

Kinetics and mechanisms of racemization: 5-Substituted hydantoins (= imidazolidine-2,4-diones) as models of chiral drugs

A chiral center in a drug molecule increases the complexity of synthetic, metabolic, pharmacological, and clinical studies, an additional problem being a possible lack of configurational stability. Here, we report detailed kinetic and mechanistic studies on the deuteration and racemization of seven 5-monosubstituted hydantoins ( = imidazolidine-2,4-diones) used as model compounds. Using 1H-NMR and chiral RP-HPLC, rates of reaction and thermodynamic parameters of activation were determined for the reactions of deuteration and racemization. Energies of deprotonation were obtained by molecular-orbital calculations performed at the AMI level. It is demonstrated that the deuteration and racemization of 5-monosubstituted hydantoins follow general-base catalysis. The identical (within experimental errors) activation energies of deuteration and racemization indicate that the two reactions share a common reaction mechanism. The fact that the pseudo-first-order rate constants of deuteration are about half of those of racemization suggests that deuteration occurs with inversion of configuration. Very large differences in reaction rates were observed between the seven compounds, indicating the marked influence of substituents on chiral stability. These results, together with the small isotope effects observed, and the comparison between experimental activation energies and calculated energies of deprotonation, suggest a S(E)2 push-pull mechanism for the racemization of 5-monosubstituted hydantoins.

Footprint catalysis. IX. Molecular footprint catalytic cavities imprinted with chiral hydantoins; enantioselective hydantoinase mimics

Imprinting using chiral 5-phenyhydantoins ((5R)- and (5S)-5-pheny-2,4-imidazolinedione) as templates could mark chiral molecular footprint-like cavities on a silica (alumina) gel surface. These cavities displayed evident enantioselective catalyses in reac