41865-46-7

Basic information

• Product Name: 3-(4-FLUOROPHENYL)PROPIOPHENONE
• Synonyms: 3-(4-FLUOROPHENYL)PROPIOPHENONE
• CAS NO: 41865-46-7
• Molecular Formula: C₁₅H₁₃FO
• Molecular Weight: 228.26
• Mol File: 41865-46-7.mol
• Article Data: 63

Chemical Properties

• Boiling Point: 357.7°C at 760 mmHg
• Flash Point: 149.6°C
• Appearance: /
• Density: 1.127g/cm³
• Vapor Pressure: 2.69E-05mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 3-(4-FLUOROPHENYL)PROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-FLUOROPHENYL)PROPIOPHENONE(41865-46-7)
• EPA Substance Registry System: 3-(4-FLUOROPHENYL)PROPIOPHENONE(41865-46-7)

Safety Data

• Hazardous Substances Data: 41865-46-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H13FO/c16-14-9-6-12(7-10-14)8-11-15(17)13-4-2-1-3-5-13/h1-7,9-10H,8,11H2

Upstream product

• 1608-51-1 4-fluorochalcone 
• 459-56-3 4-fluorobenzylic alcohol 
• 98-85-1 1-Phenylethanol 
• 1608-51-1 4-fluorochalcone 
• 67-56-1 methanol 
• 109-77-3 malononitrile 
• 459-57-4 4-fluorobenzaldehyde 
• 98-86-2 acetophenone 
• 936-59-4 3-chloropropiophenone 
• 1765-93-1 4-fluoroboronic acid 
• 405-99-2 para-fluorostyrene 
• 36952-37-1 N-(3-methylpyridin-2-yl)-1-phenylmethanimine 
• 536-74-3 phenylacetylene 
• 65-85-0 benzoic acid 

Downstream Products

• 1180676-66-7 ethyl 5-(4-fluorophenyl)-3-phenylpent-2-enoate 
• 1180676-65-6 ethyl 5-(4-fluorophenyl)-3-phenylpent-2-enoate 
• 1608-51-1 4-fluorochalcone 

Relevant articles and documents

Nickel-catalyzed α-alkylation of ketones with benzyl alcohols

We reported an efficient method for α-alkylation of ketones with benzyl alcohols using the pyridine-bridged pincer-type N-heterocyclic carbenes nickel complexes as catalysts. A wide range of ketones and benzyl alcohols were efficiently converted into various alkylated products in moderate to high yields. In addition, these nickel complexes were also successfully applied for the synthesis of a wide range of quinoline derivatives.

Novel bispidine-monoterpene conjugates—Synthesis and application as ligands for the catalytic ethylation of chalcones

A number of new chiral bispidines containing monoterpenoid fragments have been ob-tained. The bispidines were studied as ligands for Ni-catalyzed addition of diethylzinc to chalcones. The conditions for chromatographic analysis by HPLC-UV were developed,

Iridium Complexes as Efficient Catalysts for Construction of α-Substituted Ketones via Hydrogen Borrowing of Alcohols in Water

Ketones are of great importance in synthesis, biology, and pharmaceuticals. This paper reports an iridium complexes-catalyzed cross-coupling of alcohols via hydrogen borrowing, affording a series of α-alkylated ketones in high yield (86 %–95 %) and chemoselectivities (>99 : 1). This methodology has the advantages of low catalyst loading (0.1 mol%) and environmentally benign water as the solvent. Studies have shown the amount of base has a great impact on chemoselectivities. Meanwhile, deuteration experiments show water plays an important role in accelerating the reduction of the unsaturated ketones intermediates. Remarkably, a gram-scale experiment demonstrates this methodology of iridium-catalyzed cross-coupling of alcohols has potential application in the practical synthesis of α-alkylated ketones.