41929-26-4Relevant articles and documents
Organic synthesis method of scutellarein
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, (2020/07/12)
The invention provides an organic synthesis method of scutellarein, wherein the organic synthesis method comprises the following steps: 1) by using p-methoxycinnamic acid as a raw material, synthesizing p-methoxycinnamoyl chloride under the catalytic action of an acyl chloride reagent and a catalyst; step 2) carrying out esterification reaction on p-methoxycinnamoyl chloride and 3,4,5-trimethoxyphenol under the action of Lewis acid, and then carrying out Fries rearrangement, so as to obtain 9-hydroxy-5,6,7,4'-tetramethoxychalcone; step 3) performing intramolecular cyclization on the 9-hydroxy-5,6,7,4'-tetramethoxychalcone under the action of an oxidizing agent to obtain 5,6,7,4'-tetramethoxyflavone; and step 4) demethylating the 5,6,7,4'-tetramethoxyflavone under the protection of N2 underthe action of a demethylating reagent to generate scutellarin. As the reaction operation is simple and safe, the post-treatment operation is easy, and the yield is high, the method has a wide industrial application prospect.
Regioselective hydroxylation of 2-hydroxychalcones by dimethyldioxirane towards polymethoxylated flavonoids
Chu, Han-Wei,Wu, Huan-Ting,Lee, Yean-Jang
, p. 2647 - 2655 (2007/10/03)
The flavone nucleus is part of a large number of natural products and medicinal compounds. In this presentation the novel regioselective hydroxylation of hydroxyarenes with DMD is described. The results showed further that flavonoids with 5-hydroxy group were selectively oxyfunctionalized at the para-position C8 carbon atom by DMD. Finally, according to this methodology, the naturally occurring isosinensetin, tangeretin, sinensetin, nobiletin, natsudaidain, gardenin B, 3,3′,4′,5,6,7,8- heptamethoxyflavone, quercetin and its derivatives were synthesized.
Synthesis of 5,6,7,4'-tetramethoxyflavanone and 5,6,7-trimethoxy-3',4'-methylenedioxyflavone
Bidhendi, G. Nabaei,Bannerjee, N. R.
, p. 352 - 353 (2007/10/02)
The title compounds (I and II) have been synthesized by chalkone route, employing 2-hydroxy-4,4',5',6'-tetramethoxychalcone (III) and 2'-hydroxy-4',5',6'-trimethoxy-3,4-methylenedioxychalkone (IV), respectively.