419563-23-8 Usage
Description
(1R,4S) Methyl 4-aminocyclopent-2-ene-1-carboxylate D-tartrate, also known as Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid, is an organic compound that serves as an intermediate in the synthesis of ent-Abacavir (A105015), an enantiomer of Abacavir (A105000). (1R,4S) Methyl 4-aminocyclopent-2-ene-1-carboxylate D-tartrate plays a crucial role in the development of anti-HIV drugs due to its involvement in the synthesis process.
Uses
Used in Pharmaceutical Industry:
(1R,4S) Methyl 4-aminocyclopent-2-ene-1-carboxylate D-tartrate is used as an intermediate in the synthesis of ent-Abacavir (A105015) for the development of anti-HIV drugs. Ent-Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor that helps in treating HIV infection. (1R,4S) Methyl 4-aminocyclopent-2-ene-1-carboxylate D-tartrate is essential in the production of Abacavir, which is metabolized in the liver to its active form, carbovir-triphosphate (CBV-TP), that selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. This makes it a vital component in the fight against HIV and AIDS.
Check Digit Verification of cas no
The CAS Registry Mumber 419563-23-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,1,9,5,6 and 3 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 419563-23:
(8*4)+(7*1)+(6*9)+(5*5)+(4*6)+(3*3)+(2*2)+(1*3)=158
158 % 10 = 8
So 419563-23-8 is a valid CAS Registry Number.
419563-23-8Relevant articles and documents
Chemical preparation method of 2-azabicyclo [2.2.1] hept-5-ene-3-one with optical activity
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Paragraph 0023-0028; 0041-0046; 0059-0064, (2020/05/08)
The invention discloses a chemical preparation method of 2-azabicyclo [2.2.1] hept-5-ene-3-one with optical activity. The chemical preparation method comprises the following steps: racemic 2-azabicyclo [2.2.1] hept-5-ene-3-one which is easily available on the market is used as a raw material and is subjected to chemical resolution to obtain (+/-) 4-aminocyclopent-2-ene-1-carboxylic acid methyl ester with optical activity, (+/-) 4-aminocyclopent-2-ene-1-carboxylic acid is prepared by hydrolysis, and the (+/-) 4-aminocyclopent-2-ene-1-carboxylic acid is subjected to intramolecular condensation to obtain the 2-azabicyclo [2.2.1] hept-5-ene-3-one with optical activity. The method has the advantages that the use of an enzyme fermentation method is avoided, the repeatability is good, and the yield is high.
Process for preparing (-)-(1S, 4R) N-protected 4-amino-2-cyclopentene-1-carboxylate esters
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, (2008/06/13)
The invention relates to a process for preparing (?)-(1S,4R) N protected 4-amino-2-cylcopentene-1-carboxylate esters represented by the formula (I) wherein R1 and R2 are as described within the specification.
