251326-99-5 Usage
Description
(1R-4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]2-Cyclopentene-1-carboxylic acid methyl ester is a complex organic compound with a specific stereochemistry and functional groups that contribute to its unique properties and potential applications.
Uses
Used in Pharmaceutical Industry:
(1R-4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]2-Cyclopentene-1-carboxylic acid methyl ester is used as a key intermediate in the synthesis of a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist. This dual antagonist has potential applications in the treatment of various inflammatory and autoimmune diseases, as well as in the development of novel therapeutic strategies for conditions such as HIV and cancer.
The compound's unique structure and functional groups allow it to interact with the CCR2 and CCR5 receptors, blocking their activation and thus modulating the immune response. This dual antagonistic activity makes it a valuable tool in the development of new drugs targeting these receptors, which play a crucial role in the pathogenesis of several diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 251326-99-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,1,3,2 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 251326-99:
(8*2)+(7*5)+(6*1)+(5*3)+(4*2)+(3*6)+(2*9)+(1*9)=125
125 % 10 = 5
So 251326-99-5 is a valid CAS Registry Number.
251326-99-5Relevant articles and documents
CYCLOALKANE-1,3-DIAMINE DERIVATIVE
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, (2021/09/03)
The present invention provides a compound or a pharmaceutically acceptable salt thereof having an inhibitory action on the interaction between menin and an MLL protein. The compound represented by the formula (1) or a pharmaceutically acceptable salt thereof. wherein, in the formula (1), the dotted circle, R1, R2, R3, R4, R5, R6, R7, R8, Ring Q1, W, m and n are each as defined in the description.
PYRIMIDINE AND PYRIDINE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF
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Page/Page column 128, (2017/12/28)
Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing influenza.
Chiral aminocyclopentene-based cycloaddition strategies to bicyclic [3.3.0] rings
Cai, Chaozhong,Kang, Fu-An,Beauchamp, Derek A.,Sui, Zhihua,Russell, Ronald K.,Teleha, Christopher A.
, p. 651 - 656 (2013/07/05)
Two cycloaddition methods were applied to chiral protected aminocyclopentenes 2 and 9 and provided novel bicyclic products 3 and 4 in good yields. The explanation for the observed stereochemistry was based on the sterically encumbered β-face forcing the c
