41988-52-7

Basic information

• Product Name: 1-cyano-2-(4-methoxyphenyl)guanidine
• CAS NO: 41988-52-7
• Molecular Formula: C₉H₁₀N₄O
• Molecular Weight: 190.2019
• Mol File: 41988-52-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 351.2°C at 760 mmHg
• Flash Point: 166.2°C
• Density: 1.2g/cm³
• Vapor Pressure: 4.17E-05mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 1-cyano-2-(4-methoxyphenyl)guanidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyano-2-(4-methoxyphenyl)guanidine(41988-52-7)
• EPA Substance Registry System: 1-cyano-2-(4-methoxyphenyl)guanidine(41988-52-7)

Safety Data

• Hazardous Substances Data: 41988-52-7(Hazardous Substances Data)

Usage

Potential pharmacological properties

+ Antidiabetic agent
+ Calcium ion channel blocker (implications for the treatment of cardiovascular diseases)
+ Treatment of central nervous system disorders
Further research is ongoing to explore the full range of potential applications for this compound.

Upstream product

• 15760-26-6 3-cyano-2-methylisothiourea 
• 104-94-9 4-methoxy-aniline 
• 127099-85-8 N-Cyanoguanidine 
• 20265-97-8 p-anisidine hydrochloride 
• 1934-75-4 sodium dicyanamide 

Downstream Products

• 13519-16-9 N-(4-methoxyphenyl)cyanamide 
• 67453-80-9 1-(4-methoxyphenyl)guanidine 
• 86320-02-7 N-(4-Methoxy-phenyl)-N'-(4-oxo-3,4,5,6,7,8-hexahydro-benzo[4,5]thieno[2,3-d]pyrimidin-2-yl)-guanidine 
• 86327-87-9 N-(4-Methoxy-phenyl)-N'-(4-oxo-3,4-dihydro-quinazolin-2-yl)-guanidine 

Relevant articles and documents

Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases

Drug repurposing (=drug repositioning) is an effective way to cut costs for the development of new therapeutics and to reduce the time-to-market time-span. Following this concept a small library of compounds was screened for their ability to act as inhibitors of acetyl- and butyrylcholinesterase. Picloxydine, an established antiseptic, was shown to be an inhibitor for both enzymes. Systematic variation of the aryl substituents led to analogs possessing almost the same good properties as gold standard galantamine hydrobromide.