67453-80-9Relevant articles and documents
Discovery of CDK5 Inhibitors through Structure-Guided Approach
Khair, Nishat Z.,Lenjisa, Jimma L.,Tadesse, Solomon,Kumarasiri, Malika,Basnet, Sunita K. C.,Mekonnen, Laychiluh B.,Li, Manjun,Diab, Sarah,Sykes, Matthew J.,Albrecht, Hugo,Milne, Robert,Wang, Shudong
supporting information, p. 786 - 791 (2019/05/17)
Specific abrogation of cyclin-dependent kinase 5 (CDK5) activity has been validated as a viable approach for the development of anticancer agents. However, no selective CDK5 inhibitor has been reported to date. Herein, a structure-based in silico screenin
IMIDAZOPYRIDINE AMINE COMPOUND, METHOD FOR PRODUCING THE SAME AND USE OF THE SAME
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Paragraph 0121, (2016/12/01)
PROBLEM TO BE SOLVED: To provide: an unprecedented imidazopyridine amine compound having excellent neurocyte differentiation promoting activity and high safety; a pharmaceutically acceptable salt or a solvate thereof; an application thereof; and a production method therefor. SOLUTION: There are provided: an imidazopyridine amine compound represented by the formula 1; a pharmaceutical composition comprising a pharmaceutically acceptable salt or a solvate thereof; and a neurocyte differentiation promotor. [R1 to R3 each independently represent H, halogen or the like; R1 and R2 or R1 and R3 may form an unsubstituted/substituted 5- to 8-membered heterocyclic ring together with an N atom; m represents an integer of 0 to 2; and A ring represents a substituted/unsubstituted carbon ring or a hetero ring.] SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPOandINPIT
Direct guanylation of amino groups by cyanamide in water: Catalytic generation and activation of unsubstituted carbodiimide by scandium(iii) triflate
Tsubokura, Kazuki,Iwata, Takayuki,Taichi, Misako,Kurbangalieva, Almira,Fukase, Koichi,Nakao, Yoichi,Tanaka, Katsunori
, p. 1302 - 1306 (2014/06/10)
Guanylation proceeded efficiently upon treatment of the various amines with cyanamide in the presence of catalytic amounts of scandium(III) triflate under mild conditions. The method did not require the guanylation reagents to be preactivated, and the reaction proceeded efficiently in water. The method, therefore, has practical utility for substrates that dissolve only in aqueous solutions, for example, peptides or pharmacologically important compounds. Georg Thieme Verlag Stuttgart New York.