41997-47-1

Basic information

• Product Name: (S)-(+)-1,1-DIPHENYL-2-PROPANOL
• Synonyms: (S)-1,1-DIPHENYLPROPAN-2-OL;(S)-(+)-1,1-Diphenyl-2-propanol ,98% [98% ee (GLC, chiral column: Chirasil-dex CB)];(S)-(+)-1,1-DIPHENYL-2-PROPANOL
• CAS NO: 41997-47-1
• Molecular Formula: C₁₅H₁₆O
• Molecular Weight: 212.29
• Product Categories: Alcohols and Epoxides;CHIRAL CHEMICALS;Chiral Compound
• Mol File: 41997-47-1.mol
• Article Data: 30

Chemical Properties

• Melting Point: 59-62°C
• Appearance: /
• CAS DataBase Reference: (S)-(+)-1,1-DIPHENYL-2-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-1,1-DIPHENYL-2-PROPANOL(41997-47-1)
• EPA Substance Registry System: (S)-(+)-1,1-DIPHENYL-2-PROPANOL(41997-47-1)

Safety Data

• Hazardous Substances Data: 41997-47-1(Hazardous Substances Data)

Usage

General Description

(S)-(+)-1,1-Diphenyl-2-propanol is a compound with the chemical formula C15H16O. It is a chiral compound, meaning it has non-superimposable mirror images. (S)-(+)-1,1-DIPHENYL-2-PROPANOL is often used as a chiral auxiliary in organic synthesis, particularly in asymmetric synthesis, due to its ability to influence the stereochemistry of reactions. It can also be used as a resolving agent to separate racemic mixtures of compounds into their individual enantiomers. Additionally, this compound has been studied for its potential pharmacological properties, including its ability to inhibit the growth of certain cancer cells. Overall, (S)-(+)-1,1-Diphenyl-2-propanol has important applications in organic synthesis and potential medicinal uses.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 947-91-1 Diphenylacetaldehyde 
• 781-35-1 1,1-diphenylacetone 
• 64-17-5 ethanol 
• 908093-98-1 diazodiphenylmethane 
• 75-65-0 tert-butyl alcohol 
• 778-66-5 1,1-diphenyl-1-propene 
• 4741-91-7 1,2-epoxy-1,1-diphenylpropane 
• 52248-11-0 phthalic acid mono-((S)-1-methyl-2,2-diphenyl-ethyl ester) 
• 46755-94-6 (S)-1,1-diphenyl-1,2-propanediol 
• 41997-47-1 1,1-diphenyl-2-propanol 
• 108-05-4 vinyl acetate 
• 52199-75-4 (+/-)-phthalic acid mono-(1-methyl-2,2-diphenyl-ethyl ester) 
• 54783-75-4 (S)-2-(benzyloxy)-1,1-diphenylpropan-1-ol 

Downstream Products

• 52199-75-4 (+/-)-phthalic acid mono-(1-methyl-2,2-diphenyl-ethyl ester) 
• 7693-88-1 (1S,2S)-1-chloro-1,2-diphenyl-propane 
• 7693-88-1 (1RS,2RS)-1-chloro-1,2-diphenyl-propane 
• 7693-88-1 (1RS,2SR)-1-chloro-1,2-diphenyl-propane 
• 108974-25-0 (+/-)-acetic acid-(1-methyl-2,2-diphenyl-ethyl ester) 
• 102599-29-1 (R)-2-benzoyloxy-1,1-diphenyl-propane 
• 123525-61-1 methyl 1,1-diphenyl-2-propyl ether 
• 24435-40-3 erythro-1-amino-1,2-diphenylpropane 
• 24435-40-3 1,2-diphenylpropan-1-amine(anti-3ak)and 
• 52248-11-0 phthalic acid mono-((S)-1-methyl-2,2-diphenyl-ethyl ester) 
• 52199-75-4 phthalic acid mono-((R)-1-methyl-2,2-diphenyl-ethyl ester) 
• 833-81-8 1,2-diphenylpropene 
• 29338-49-6 (S)-(-)-1,1-diphenylpropan-2-ol 
• 29338-49-6 (R)-(+)-1,1-diphenylpropan-2-ol 

Relevant articles and documents

Manganese catalyzed asymmetric transfer hydrogenation of ketones

The asymmetric transfer hydrogenation (ATH) of a wide range of ketones catalyzed by manganese complex as well as chiral PxNy-type ligand under mild conditions was investigated. Using 2-propanol as hydrogen source, various ketones could be enantioselectively hydrogenated by combining cheap, readily available [MnBr(CO)5] with chiral, 22-membered macrocyclic ligand (R,R,R',R')-CyP2N4 (L5) with 2 mol% of catalyst loading, affording highly valuable chiral alcohols with up to 95% ee.

A General Regioselective Synthesis of Alcohols by Cobalt-Catalyzed Hydrogenation of Epoxides

A straightforward methodology for the synthesis of anti-Markovnikov-type alcohols is presented. By using a specific cobalt triphos complex in the presence of Zn(OTf)2 as an additive, the hydrogenation of epoxides proceeds with high yields and selectivities. The described protocol shows a broad substrate scope, including multi-substituted internal and terminal epoxides, as well as a good functional-group tolerance. Various natural-product derivatives, including steroids, terpenoids, and sesquiterpenoids, gave access to the corresponding alcohols in moderate-to-excellent yields.

Manganese Catalyzed Asymmetric Transfer Hydrogenation of Ketones Using Chiral Oxamide Ligands

The asymmetric transfer hydrogenation of ketones using isopropyl alcohol (IPA) as hydrogen donor in the presence of novel manganese catalysts is explored. The selective and active systems are easily generated in situ from [MnBr(CO)5] and inexpensive C2-symmeric bisoxalamide ligands. Under the optimized reaction conditions, the Mn-derived catalyst gave higher enantioselectivity compared with the related ruthenium catalyst.