4206-94-4Relevant articles and documents
Fontal et al.
, p. 2424 (1966)
Preparation method for methylethylphosphinic acid and aluminum salt thereof
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Paragraph 0045-0049; 0053-0057, (2019/10/01)
The invention discloses a preparation method for methylethylphosphinic acid and an aluminum salt thereof, belonging to the technical field of organic synthesis. To reduce the production cost of methylethylphosphinic acid and improve the purity of methylethylphosphinic acid, the invention provides the preparation method for methylethylphosphinic acid and the aluminum salt thereof. The preparation method comprises the following steps: reacting dichloromethylphosphine with water to obtain an aqueous dichloromethylphosphine solution; with di-tert-butyl peroxide as an initiator, reacting the aqueous dichloromethylphosphine solution with ethylene so as to obtain methylethylphosphinic acid; and reacting the methylethylphosphinic acid with an aqueous solution of Al(SO).18HO to obtain the aluminum salt of methylethylphosphinic acid. According to the invention, the aqueous dichloromethylphosphine solution is directly used for preparing the methylethylphosphinic acid, reaction conditions are screened so as to realize high-yield preparation of high-purity methylethylphosphinic acid, and the high-purity methylethylphosphinic acid is directly used for preparing the aluminum salt of methylethylphosphinic acid; so the purification operation of each intermediate is eliminated, which allows production efficiency to be significantly improved and production cost to be reduced.
PROCESS FOR PREPARING METHYL PHOSPHINIC ACID BUTYL ESTER
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Page/Page column 39; 40, (2018/09/19)
The present subject matter provides a safe alternative for producing an important intermediate useful for preparing the herbicide glufosinate, without need for chlorine components in the manufacturing process. In particular, a process for preparing alkyl phosphinic aid alkyl ester is provided, including the step of alkylating alkyl phosphinic acid ester in a non-polar solvent in the same apparatus as used to first produce the alkyl phosphinic acid ester, and without isolating the alkyl phosphinic acid ester before the alkylation step is conducted. More specifically, a process is presented for preparing methyl phosphinic acid butyl ester, by alkylating butyl phosphinic acid ester in a non-polar solvent, in the same' apparatus as used previously to first produce the butyl phosphinic acid ester and without isolating the butylphosphinic acid ester before alkylation.
