42205-75-4

Basic information

• Product Name: (2R,4R)-ethyl 4-Methylpiperidine-2-carboxylate
• Synonyms: (2R,4S)-ethyl 4-methylpiperidine-2-carboxylate(WX900194)
• CAS NO: 42205-75-4
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.23678
• Mol File: 42205-75-4.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 226.1±33.0 °C(Predicted)
• Appearance: /
• Density: 0.969±0.06 g/cm3(Predicted)
• PKA: 6.65±0.10(Predicted)
• CAS DataBase Reference: (2R,4R)-ethyl 4-Methylpiperidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-ethyl 4-Methylpiperidine-2-carboxylate(42205-75-4)
• EPA Substance Registry System: (2R,4R)-ethyl 4-Methylpiperidine-2-carboxylate(42205-75-4)

Safety Data

• Hazardous Substances Data: 42205-75-4(Hazardous Substances Data)

Upstream product

• 4021-08-3 4-methylpicolinic acid 
• 71-41-0 pentan-1-ol 
• 123387-50-8 4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 162167-52-4 (2R-trans)-1-[(Phenylmethoxy)carbonyl]-4-methyl-2-piperidinecarboxylic acid, ethyl ester 
• 64-17-5 ethanol 
• 134984-62-6 ethyl cis-(2S,4R)-1-<(R)-1-phenylethyl>-4-methylpipecolate 
• 134984-61-5 (6S)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-4-methyl-3,4-didehydropiperidine 
• 78-79-5 isoprene 
• 66937-93-7 4(R)-Methylpiperidine-2(R)-carboxylic acid ethyl ester 
• 134984-62-6 (2R,4R)-4-Methyl-1-((R)-1-phenyl-ethyl)-piperidine-2-carboxylic acid ethyl ester 
• 139334-62-6 (6R)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-4-methyl-3,4-didehydropiperidine 
• 139334-63-7 ethyl (2R)-4-methyl-1-((S)-1-phenylethyl)-1,2,3,6-tetrahydropyridine-2-carboxylate 
• 198641-56-4 ethyl (2R,4R)-4-methyl-1-((S)-1-phenylethyl)tetrahydropyridine-2-carboxylate 
• 626-58-4 4-methylpiperidin 

Downstream Products

• 74863-81-3 ethyl 1-α-(tert-butoxycarbonyl)-N^ω-nitro-L-arginyl>-4-methyl-2-piperidinecarboxylate 
• 4939-37-1 2-methylquinolizidine 
• 131278-84-7 ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate L-(+)-tartarate 
• 1401618-23-2 ethyl (2S,4S)-4-methyl-2-piperidinecarboxylate L-tartrate 
• 79199-62-5 ethyl (2S,4R)-4-methylpipecolate 
• 74874-07-0 ethyl (2R,4R)-1-[(2S)-2-[[(1,1-dimethyletoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate 
• 74874-07-0 ethyl (2R,4R)-1-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate 
• 1401618-20-9 ethyl (2S,4S)-1-[(2S)-2-[[(1,1-dimethyletoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate 
• 74892-82-3 ethyl (2R-trans)-4-methylpiperidine-2-carboxylate 
• 1401618-20-9 ethyl (2S,4S)-1-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate 

Relevant articles and documents

Method for splitting isomer impurity of agathiban starting material

The invention provides a method for splitting the isomer impurity of an argatroban starting material. The method comprises the following steps: performing salt formation by taking 4-methyl-2-piperidinecarboxylate racemate as a raw material and taking D-(+

Method of resolving argatroban starting material isomer impurities

The invention provides a method of resolving argatroban starting material isomer impurities. The method includes: with ethyl 4-methyl-2-piperidinecarboxylate racemate as a raw material and L-(-)-dibenzoyltartaric acid as a resolving agent, salifying to obtain ethyl (2R,4S)-4-methyl-2-piperidinecarboxylate-L-(-)-dibenzoyltartrate shown as a compound I, freeing the compound I under alkaline conditions to obtain ethyl (2R,4S)-4-methyl-2-piperidinecarboxylate shown as a compound II. The method provided herein is simple to perform, and has total resolving yield of 45.2% and post-resolving chiral purity of 99.2%.

Synthesis method of argatroban intermediate (2R,4R)-4-methyl piperidine-2-ethyl formate

The invention relates to a synthesis method of an argatroban intermediate (2R,4R)-4-methyl piperidine-2-ethyl formate compound. The synthesis method comprises the following steps: (1) under the action of a rhodium catalyst and ferric oxalate, carrying out catalytic hydrogenation on (2R)-4-methyl-1-((S)-1-phenethyl)-1,2,3,6-tetrahydropyridine-2-ethyl formate, so that (2R,4R)-4-methyl-1-((S)-1-phenethyl)-2-pyridine ethyl formate is obtained; and (2) under the action of a palladium catalyst and ferric oxalate, removing benzyl, so that the (2R,4R)-4-methyl piperidine-2-ethyl formate is obtained. The synthesis method provided by the invention has the advantages that the ferric oxalate is introduced into a reaction system, two-step reaction yield is increased, especially the efficiency is the highest when the ferric oxalate and a rhodium-silicon dioxide catalyst are used together, and the cost is effectively reduced, so that the synthesis method is applicable to industrial production.