42365-68-4

Basic information

• Product Name: 3-HYDROXY-4-METHOXYBENZYLAMINE HYDROCHLORIDE
• Synonyms: ISOVANILLYLAMINE HCL;ISOVANILLYLAMINE HYDROCHLORIDE;5-AMINOMETHYL-2-METHOXYPHENOL HYDROCHLORIDE;3-HYDROXY-4-METHOXYBENZYLAMINE HCL;3-HYDROXY-4-METHOXYBENZYLAMINE HYDROCHLORIDE;3-Hydroxy-4-methoxybenzylamine hydrochloride 97%;3-Hydroxy-4-methoxybenzylamine hydrochloride, 4-(Aminomethyl)-2-hydroxyanisole hydrochloride;5-(Aminomethyl)-2-methoxyphenol hydrochloride 97%
• CAS NO: 42365-68-4
• Molecular Formula: C₈H₁₁NO₂*ClH
• Molecular Weight: 189.64
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Amino Alcohols;Organic Building Blocks;Oxygen Compounds;Amino Alcohols;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 42365-68-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 190-195 °C(lit.)
• Boiling Point: 295.3 °C at 760 mmHg
• Flash Point: 132.4 °C
• Appearance: /
• Density: 1.161g/cm3
• Vapor Pressure: 0.000871mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-HYDROXY-4-METHOXYBENZYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXY-4-METHOXYBENZYLAMINE HYDROCHLORIDE(42365-68-4)
• EPA Substance Registry System: 3-HYDROXY-4-METHOXYBENZYLAMINE HYDROCHLORIDE(42365-68-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 42365-68-4(Hazardous Substances Data)

Usage

General Description

3-HYDROXY-4-METHOXYBENZYLAMINE HYDROCHLORIDE is a chemical compound with the molecular formula C9H14ClNO2. It is a derivative of 4-methoxybenzylamine and is commonly used as a pharmaceutical intermediate in the synthesis of various drugs. 3-HYDROXY-4-METHOXYBENZYLAMINE HYDROCHLORIDE has been found to have potential therapeutic applications in the treatment of conditions such as depression, anxiety, and neurodegenerative diseases. It functions as a selective and reversible inhibitor of monoamine oxidase (MAO) and has shown promise in preclinical studies for its ability to modulate neurotransmitter levels in the brain. Additionally, 3-HYDROXY-4-METHOXYBENZYLAMINE HYDROCHLORIDE has been investigated for its potential role in anti-aging and anti-cancer therapies due to its ability to reduce oxidative stress and inflammation.

InChI:InChI=1/C8H11NO2/c1-11-8-3-2-6(5-9)4-7(8)10/h2-4,10H,5,9H2,1H3

Upstream product

• 222533-34-8 N-(3-hydroxy-4-methoxy-benzyl)-acetamide 
• 98910-57-7 2-methoxyphenyl mesylate 
• 222533-31-5 methanesulfonic acid 5-(acetylamino-methyl)-2-methoxy-phenyl ester 
• 621-59-0 isovanillin 

Downstream Products

• 943347-54-4 (4Z)-5-bromo-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione 
• 1620085-95-1 6-amino-7-(1H-benzo[d]imidazol-2-yl)-5-(3-hydroxy-4-methoxybenzyl)-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitrile 
• 161832-13-9 tert-butyl 3-hydroxy-4-methoxybenzylcarbamate 

Relevant articles and documents

Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines

The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni-tartaric acid complex on silica is presented. The resulting stable and reusable Ni-nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of molecular hydrogen. Applying this Ni-based amination protocol, -NH2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.

APPLICATIONS OF N6-SUBSTITUTED ADENOSINE DERIVATIVE AND N6-SUBSTITUTED ADENINE DERIVATIVE TO CALMING, HYPNOSES, CONVULSION RESISTANCE, EPILEPTIC RESISTANCE, PARKINSON DISEASE RESISTANCE, AND DEMENTIA PREVENTION AND TREATMENT

PROBLEM TO BE SOLVED: To prepare analgesics, hypnotic agents, anticonvulsant agents, antiepileptics, antiparkinson drugs, dementia prophylactics, and health care food. SOLUTION: The present invention relates to an N6-substituted adenosine derivative and an N6-substituted adenine derivative selected from the group consisting of specific compounds. The present invention also relates to a pharmaceutical composition at least comprising a therapeutically effective amount of the compounds and a pharmaceutically acceptable carrier. The invention further relates to the compounds used in preparation of analgesics, hypnotic agents, anticonvulsant agents, antiepileptics, antiparkinson drugs, dementia prophylactics, and health care food. COPYRIGHT: (C)2016,JPO&INPIT

N6-SUBSTITUTED ADENOSINE DERIVATIVES, N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF

The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.