42393-65-7

Basic information

• Product Name: Benzenamine, N-(2-chloroethyl)-N-phenyl-
• CAS NO: 42393-65-7
• Molecular Formula: C14H14ClN
• Molecular Weight: 231.725
• Mol File: 42393-65-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenamine, N-(2-chloroethyl)-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N-(2-chloroethyl)-N-phenyl-(42393-65-7)
• EPA Substance Registry System: Benzenamine, N-(2-chloroethyl)-N-phenyl-(42393-65-7)

Safety Data

• Hazardous Substances Data: 42393-65-7(Hazardous Substances Data)

Upstream product

• 140-08-9 tris(2-chloro-ethyl)phosphite 
• 98-95-3 nitrobenzene 
• 98-80-6 phenylboronic acid 
• 122-39-4 diphenylamine 
• 79-11-8 chloroacetic acid 

Downstream Products

• 42393-74-8 (C₆H₅)3SnCH₂CH₂N(C₆H₅)2 
• 1103310-81-1 [1-(2-diphenylamino-ethyl)-piperidin-4-yl]-acetic acid methyl ester 
• 1103511-05-2 C₂₇H₃₁N₃O 
• 1104937-66-7 1-(2-diphenylamino-ethyl) piperidine-4-carboxylic acid ethyl ester 
• 138354-51-5 1-(4-Chloro-phenyl)-3-(2-diphenylamino-ethyl)-urea 
• 86922-19-2 2-Isopropyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid (2-diphenylamino-ethyl)-amide 
• 1140-29-0 N-(2-aminoethyl)-N-phenylaniline 
• 86922-38-5 2-<2-(diphenylamino)ethyl>-1H-isoindole-1,3(2H)-dione 
• 127556-76-7 1-(2-dibenzylaminoethyl)-5-methoxy-2-ethoxycarbonylindole 

Relevant articles and documents

DUAL INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE AND 5-LIPOXYGENASE

The invention pertains to a novel structure (I) that provides an activity as a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and 5-lipoxygenase (5-LOX). The invention pertains to multiple derivatives of the new class of dual inhibitors, their application in medicine, pharmaceutical compositions comprising them as well as to methods for synthesizing the new compounds.

Transition-Metal-Free Three-Component Synthesis of Tertiary Aryl Amines from Nitro Compounds, Boronic Acids, and Trialkyl Phosphites

The synthesis of aromatic amines is of continuous interest in chemistry. An exceptionally versatile three-component reaction that directly transforms inexpensive nitro compounds, boronic acids, and trialkyl phosphites into tertiary aromatic amines has been realized. The reaction tolerates alkyl and aryl substituents on the nitro and boronic acid moieties, as well as functionalized phosphites. No transition-metal catalysis is required. The method is orthogonal to other classical metal-catalyzed syntheses since it tolerates the presence of halogens, and also permits the synthesis of functionalized compounds such as α-amino ester derivatives. (Figure presented.).

Hybrid Cholecystokinin-A Antagonists Based on Molecular Modelling of Lorglumide and L-364,718

A series of novel nonpeptide cholecystokinin-A (CCK-A) antagonists have been synthesized.Designed on the basis of the structural homology between lorgumide and L-364,718, as investigated with molecular modeling, these compounds constitute a link between the N-acylglutamic acid and 3-amino-5-phenyl-1,4-benzodiazepin-2-one derived antagonists.The prepared compounds were tested in vitro as antagonists of the binding of -(+/-)-L-364,718 and -CCK-8(S) to rat pancreas and guinea pig brain membranes, respectively.All compounds proved to be selective for the(peripheral) CCK-A receptor, the most potent analogue, 6, having a Ki value of 90 nM.The structure-activity profile of the series of hybrid compounds relates closest to that of the N-acylglutamic acid derived antagonists.