4265-14-9

Basic information

• Product Name: Benzofuran, 2-(phenylmethyl)-
• CAS NO: 4265-14-9
• Molecular Formula: C15H12O
• Molecular Weight: 208.26
• Mol File: 4265-14-9.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Benzofuran, 2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 2-(phenylmethyl)-(4265-14-9)
• EPA Substance Registry System: Benzofuran, 2-(phenylmethyl)-(4265-14-9)

Safety Data

• Hazardous Substances Data: 4265-14-9(Hazardous Substances Data)

Upstream product

• 6272-40-8 2-benzoylbenzofuran 
• 582-04-7 aurone 
• 103-82-2 phenylacetic acid 
• 292081-10-8 [2-(bis-phenylsulfanyl-methyl)-phenoxy]-tert-butyl-dimethyl-silane 
• 53074-73-0 2-(2-chloroacetyl)phenol 
• 6921-34-2 benzylmagnesium chloride 
• 1666-14-4 N’-(2-hydroxybenzylidene)-4-methylbenzene-1-sulfonohydrazide 
• 536-74-3 phenylacetylene 
• 90-02-8 salicylaldehyde 
• 91703-34-3 2-(β,β-dibromovinyl)phenol 
• 62360-00-3 (Z)-2-fluoro-3-phenylprop-2-enyl acetate 
• 108-95-2 phenol 
• 101441-88-7 2-(2-methoxy-phenyl)-4-phenyl-acetoacetonitrile 
• 62452-62-4 benzofuran-2-ylmethyl acetate 

Downstream Products

• 77071-96-6 3-acetyl-2-benzylbenzofuran 
• 55877-39-9 (2-benzyl-benzofuran-3-yl)-(4-methoxy-phenyl)-methanone 
• 13524-66-8 2-benzyldihydrobenzofuran 
• 27052-21-7 (benzofuran-2-yl)phenylmethanol 
• 6272-40-8 2-benzoylbenzofuran 
• 1418311-41-7 2-(methoxy(phenyl)methyl)benzofuran 
• 440633-77-2 2-(2-benzylbenzo[b]furan-3-yl)acetonitrile 

Relevant articles and documents

Synthesis of Indole/Benzofuran-Containing Diarylmethanes through Palladium-Catalyzed Reaction of Indolylmethyl or Benzofuranylmethyl Acetates with Boronic Acids

The palladium-catalyzed synthesis of indole/benzofurancontaining diarylmethanes starting from indolylmethyl or benzofuranylmethyl acetates with boronic acids has been investigated. The success of the reaction is influenced by the choice of precatalyst: with indolylmethyl acetates the reaction works well with [Pd(η3-C3H5)Cl]2/XPhos while with benzofuranylmethyl acetates Pd2(dba)3/XPhos is more efficient. The good to high yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2- and 3-substituted indoles and 2-benzo[b]furans. The methodology can be advantageously extended to the preparation of a key precursor of Zafirlukast.

Construction of Di(hetero)arylmethanes Through Pd-Catalyzed Direct Dehydroxylative Cross-Coupling of Benzylic Alcohols and Aryl Boronic Acids Mediated by Sulfuryl Fluoride (SO2F2)

A practical Pd-catalyzed direct dehydroxylative coupling of (hetero)benzylic alcohols with (hetero)arylboronic acids for the constructions of di(hetero)arylmethane derivatives under SO2F2 was described. This new method provided a strategically distinct approach to di(hetero)arylmethane derivatives from readily available and abundant benzylic alcohols under mild condition.

Synthesis of 2-substituted benzofuran derivatives by the palladium-catalyzed intermolecular coupling of 2-fluoroallylic acetates with phenols

We investigated the intermolecular coupling reaction of 2-fluoroallylic acetates with simple phenols by the [Pd(C3H5)Cl]2, DPPF, and KHMDS at 100?°C for 16?h, and succeeded in obtaining 2-substituted benzofuran derivatives