426842-85-5

Basic information

• Product Name: 3-fluoro-6-methoxyquinoline
• Synonyms: 3-fluoro-6-methoxyquinoline
• CAS NO: 426842-85-5
• Molecular Formula: C10H8FNO
• Molecular Weight: 177
• Mol File: 426842-85-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 284.0±20.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• PKA: 2.34±0.14(Predicted)
• CAS DataBase Reference: 3-fluoro-6-methoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-6-methoxyquinoline(426842-85-5)
• EPA Substance Registry System: 3-fluoro-6-methoxyquinoline(426842-85-5)

Safety Data

• Hazardous Substances Data: 426842-85-5(Hazardous Substances Data)

Usage

Description

3-Fluoro-6-methoxyquinoline is a quinoline derivative with the molecular formula C10H8FNO, featuring a fluorine atom at the 3-position and a methoxy group at the 6-position. It is an aromatic heterocyclic compound known for its potential applications in the pharmaceutical, chemical, and biological fields.

Uses

Used in Pharmaceutical Industry:
3-Fluoro-6-methoxyquinoline is used as a building block for the synthesis of various pharmaceutical drugs due to its unique chemical structure and properties.
Used in Organic Synthesis:
3-Fluoro-6-methoxyquinoline is used as a reagent or catalyst in organic synthesis, contributing to the development of new chemical compounds and reactions.
Used in Biological Research:
3-Fluoro-6-methoxyquinoline is studied for its potential biological activities, such as antifungal and antibacterial properties, making it a candidate for applications in the biological and medical fields.

Upstream product

• 29507-86-6 3-amino-6-methoxyquinoline 
• 1086533-18-7 2,4-dichloro-3-fluoro-6-methoxyquinoline 
• 104-94-9 4-methoxy-aniline 
• 108-18-9 diisopropylamine 
• 71083-30-2 6-methoxyquinoline-3-carboxamide 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 
• 77156-78-6 ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate 
• 22931-71-1 ethyl 4-chloro-6-methoxyquinolin-3-carboxylate 
• 26660-48-0 ethyl 6-methoxyquinoline-3-carboxylate 
• 71082-47-8 6-methoxyquinoline-3-carboxylic acid 

Downstream Products

• 808755-53-5 3-fluoroquinolin-6-ol 
• 1072793-21-5 6-fluoro-quinoline-5-carbaldehyde 
• 1080636-09-4 4-(2-(3-fluoro-6-methoxyquinolin-4-yl)-2-hydroxyethoxy)-1-(3-phenylcyclobutyl)piperidine-4-carboxylic acid 

Relevant articles and documents

Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics

A practical and scalable 4-step route is presented for the synthesis of 4-bromo-3-fluoro-6-methoxyoquinoline and 3-fluoro-4-iodo-6-methoxyoquinoline from readily available 2,4-dichloro-3-fluoroquinoline with an overall yield of 81-85%. Halogenated quinoline building blocks have found much use in antimicrobial drug discovery, and the method reported here would be useful for the synthesis of these compounds.

Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid

A scalable route to 3-fluoro-6-methoxyquinoline needed to be developed as multi-kg amounts of this heterocycle were required. Initial route development focused on the formation of the key C-F bond via a Balz-Schiemann reaction or electrophilic fluorinatio

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.