42833-84-1Relevant articles and documents
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors
Chetter, Ben A.,Kyriakis, Efthimios,Barr, Daniel,Karra, Aikaterini G.,Katsidou, Elisabeth,Koulas, Symeon M.,Skamnaki, Vassiliki T.,Snape, Timothy J.,Psarra, Anna-Maria G.,Leonidas, Demetres D.,Hayes, Joseph M.
, (2020/08/10)
Glycogen phosphorylase (GP) is an important target for the development of new anti-hyperglycaemic agents. Flavonoids are novel inhibitors of GP, but their mode of action is unspecific in terms of the GP binding sites involved. Towards design of synthetic
Synthesis and antibacterial activity of 4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl-methanone derivatives and its intermediates
Krishna Reddy,Venkateswara Rao,Bhaskar Reddy,Ram,Balram
, p. 2245 - 2248 (2015/12/01)
Encouraged by the interesting biological activities associated with benzo[b]furan derivatives, we report here the synthesis, spectroscopic identification and antibacterial activity of benzo[b]furan derivatives (6a-6g) prepared from commercially available,
Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth
Thévenin, Marion,Thoret, Sylviane,Grellier, Philippe,Dubois, Jo?lle
supporting information, p. 4885 - 4892 (2013/09/02)
A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falci
