62778-01-2

Basic information

• Product Name: (2,4,6-trimethoxyphenyl)glyoxylic acid
• Synonyms: (2,4,6-trimethoxyphenyl)glyoxylic acid
• CAS NO: 62778-01-2
• Molecular Weight: 240.213
• Mol File: 62778-01-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2,4,6-trimethoxyphenyl)glyoxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4,6-trimethoxyphenyl)glyoxylic acid(62778-01-2)
• EPA Substance Registry System: (2,4,6-trimethoxyphenyl)glyoxylic acid(62778-01-2)

Safety Data

• Hazardous Substances Data: 62778-01-2(Hazardous Substances Data)

Upstream product

• 832-58-6 1-(2,4,6-trimethoxyphenyl)ethanone 
• 621-23-8 1,2,3-trimethoxybenzene 
• 107415-19-0 ethyl 2-(2,4,6-trimethoxyphenyl)-2-oxoacetate 
• 105338-30-5 methyl 2,4,6-trimethoxyphenylglyoxylate 

Downstream Products

• 42833-84-1 2,4,6-trimethoxybenzoyl chloride 
• 1447331-42-1 N-(2-(1H-indol-3-yl)-2-oxoethyl)-2-(2,4,6-trimethoxyphenyl)-2-oxoacetamide 
• 1447330-90-6 5-(1H-indol-3-yl)-3-(2,4,6-trimethoxyphenyl)pyrazine-2(1H)-one 
• 81572-45-4 [(NH3)3Co(μ-OH)2(μ-(2,4,6-trimethoxyphenyl)glyoxylato)Co(NH3)3](ClO4)3 

Relevant articles and documents

Effective synthesis of 3,5-diaryl-(1H)-pyrazin-2-ones via microwave mediated ring closure

In this study we report on a flexible straight forward synthesis toward novel 3,5-diaryl-(1H)-pyrazin-2-ones. Our synthetic strategy involved an acyclic di-keto derivative as key intermediate. The final pyrazin-2-one ring closure reaction was yield-optimized by using a microwave mediated procedure and ammoniumacetate as nitrogen source. Our method is a suitable alternative to palladium-catalyzed coupling reactions for the 3,5-diaryl decoration of the (1H)-pyrazin-2-one scaffold. Since the (1H)-pyrazin-2-ones is present as scaffold in a number of biologically active compounds the reported synthetic platform is a useful approach to generate a set of highly diverse 3,5-diaryl-(1H)-pyrazin-2-one compounds.