4284-47-3

Basic information

• Product Name: N-(4-methylphenyl)methanesulfonamide
• Synonyms: N-(4-methylphenyl)methanesulfonamide
• CAS NO: 4284-47-3
• Molecular Formula: C₈H₁₁NO₂S
• Molecular Weight: 185.24344
• Mol File: 4284-47-3.mol
• Article Data: 35

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-methylphenyl)methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)methanesulfonamide(4284-47-3)
• EPA Substance Registry System: N-(4-methylphenyl)methanesulfonamide(4284-47-3)

Safety Data

• Hazardous Substances Data: 4284-47-3(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 124-63-0 methanesulfonyl chloride 
• 54378-81-3 C₂₇H₂₆NO₄PS₂ 
• 3144-09-0 methanesulfonamide 
• 106-38-7 para-bromotoluene 
• 106-44-5 p-cresol 
• 106-43-4 para-chlorotoluene 
• 93131-73-8 4-tolyl perfluorobutanesulfonate 
• 5720-05-8 4-methylphenylboronic acid 
• 624-90-8 Methanesulfonyl azide 
• 624-31-7 4-tolyl iodide 
• 99-99-0 1-methyl-4-nitrobenzene 
• 20277-69-4 sodium methansulfinate 

Downstream Products

• 109495-72-9 N-(2-chloro-4-methylphenyl)methanesulfonamide 
• 114723-63-6 methanesulfonic acid-(2,3,5,6-tetrachloro-4-methyl-anilide) 
• 22729-82-4 N-(1,1,2,2-Tetrachloro-2-fluoro-ethylsulfanyl)-N-p-tolyl-methanesulfonamide 
• 108297-29-6 N-(4-Methyl-2-pyrrolidin-1-ylmethyl-phenyl)-methanesulfonamide 
• 88131-57-1 N-(3,3-Diethoxy-propyl)-N-p-tolyl-methanesulfonamide 
• 88131-49-1 N-(2,2-Diethoxy-ethyl)-N-p-tolyl-methanesulfonamide 
• 4284-63-3 2-Methanesulfonyl-4-methyl-phenylamine 
• 265995-45-7 N-(4-methylphenyl)-2-hydroxyethanesulfonamide 
• 333383-71-4 N-(3-oxo-propyl)-N-p-tolyl-methanesulfonamide 
• 91-62-3 6-methylquinoline 
• 265995-37-7 N-(4-methylphenyl)-1,2-thiazetidine 1,1-dioxide 
• 265995-51-5 N-(4-methylphenyl)-2-hydroxyethanesulfonamide mesylate 
• 614-96-0 5-methyl-1H-indole 
• 10355-06-3 methyl 3-methylphenyl sulfone 

Relevant articles and documents

Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

In the present study, following a one-pot two-step protocol, we have synthesized novel sulfonamides-isoxazolines hybrids (3a-r) via a highly regioselective 1,3-dipolar cycloaddition. The present methodology capitalized on trichloroisocyanuric acid (TCCA) as a safe and ecological oxidant and chlorinating agent for the in-situ conversion of aldehydes to nitrile oxides in the presence of hydroxylamine hydrochloride, under ultrasound activation. These nitrile oxides could be engaged in 1,3-dipolar cycloaddition reactions with various alkene to afford the targeted sulfonamides-isoxazolines hybrids (3a-r). The latter were assessed for their antineoplastic activity against model leukemia cell lines (Chronic Myeloid Leukemia, K562 and Promyelocytic Leukemia, HL-60).

Copper-catalyzed redox coupling of nitroarenes with sodium sulfinates

A simple copper-catalyzed redox coupling of sodium sulfinates and nitroarenes is described. In this process, abundant and stable nitroarenes serve as both the nitrogen sources and oxidants, and sodium sulfinates act as both reactants and reductants. A variety of aromatic sulfonamides were obtained in moderate to good yields with broad substrate scope. No external additive is employed for this kind of transformation.

Facile Chan-Lam coupling using ferrocene tethered N-heterocyclic carbene-copper complex anchored on graphene

Ferrocene tethered N-heterocyclic carbene-copper complex anchored on graphene ([GrFemImi]NHC@Cu complex) has been synthesized by covalent grafting of ferrocenyl ionic liquid in the matrix of graphene followed by metallation with copper (I) iodide. The [GrFemImi]NHC@Cu complex has been characterized by fourier transform infrared (FT-IR), fourier transform Raman (FT-Raman), CP-MAS 13C NMR spectroscopy, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), energy dispersive X-ray (EDX) analysis, X-ray photoelectron spectroscopy (XPS), Brunauer–Emmett–Teller (BET) surface area analysis and X-ray diffractometer (XRD) analysis. This novel complex served as a robust heterogeneous catalyst for the synthesis of bioactive N-aryl sulfonamides from variety of aryl boronic acids and sulfonyl azides in ethanol by Chan-Lam coupling. Recyclability experiments were executed successfully for six consecutive runs.