42868-89-3

Basic information

• Product Name: (4-METHYLPHENYL)AMINO](OXO)ACETIC ACID
• Synonyms: acetic acid, [(4-methylphenyl)amino]oxo-;Albb-009514;[(4-methylphenyl)amino](oxo)acetic acid(SALTDATA: FREE);2-[(4-methylphenyl)amino]-2-oxoacetic acid;2-[(4-methylphenyl)amino]-2-oxo-acetic acid;2-[(4-methylphenyl)amino]-2-oxo-ethanoic acid;2-keto-2-[(4-methylphenyl)amino]acetic acid
• CAS NO: 42868-89-3
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.18
• Mol File: 42868-89-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (4-METHYLPHENYL)AMINO](OXO)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHYLPHENYL)AMINO](OXO)ACETIC ACID(42868-89-3)
• EPA Substance Registry System: (4-METHYLPHENYL)AMINO](OXO)ACETIC ACID(42868-89-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 42868-89-3(Hazardous Substances Data)

Usage

General Description

"(4-Methylphenyl)amino](oxo)acetic acid is a chemical compound that consists of a 4-methylphenyl group, an amino group, and an oxo group on an acetic acid backbone. It is characterized by the presence of a carboxylic acid group and an oxo group, which is typically a carbonyl group found in many organic compounds and can be reactive. The amino group serves as a base and can become protonated, leading to potential roles in acidity and basicity. The molecule's 4-methylphenyl component, part of the aromatic phenyl group, could contribute to its aromaticity, which may affect its behavior and interactions with other compounds. However, specific properties such as solubility, melting point, boiling point, and potential uses would need further investigation and experiment. In general, the structure suggests it may have relevance in fields like organic synthesis, pharmaceuticals, and materials science among others."

InChI:InChI=1/C9H9NO3/c1-6-2-4-7(5-3-6)10-8(11)9(12)13/h2-5H,1H3,(H,10,11)(H,12,13)/p-1

Upstream product

• 106-49-0 p-toluidine 
• 95-92-1 oxalic acid diethyl ester 
• 1590-78-9 (N-dichloroacetyl-4-methyl-anilino)-oxo-acetyl chloride 
• 80945-63-7 methyl 2-oxo-2-(p-tolylamino)acetate 
• 18522-98-0 ethyl 2-[(4-methylphenyl)amino]-2-oxoacetate 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 622-58-2 p-Tolylisocyanate 
• 144217-65-2 YYA-021 
• 1040762-95-5 C₂₂H₁₄BrClF₃N₃O₃ 
• 1210712-00-7 C₂₁H₂₅N₃O₂ 
• 1338471-26-3 5-fluoro-3-[(4-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid 
• 1338471-29-6 (S)-3-[(4-methyl-phenylaminooxalyl)-amino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid 
• 1338471-36-5 (S)-5-(2,6-difluorophenoxy)-3-[(4-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid 
• 494789-83-2 amino-5-methyl-N-(p-tolyl)benzamide 
• 56106-02-6 1-(4-methylphenyl)-3-(4-methoxyphenyl)urea 

Relevant articles and documents

Direct C3 Carbamoylation of 2H-Indazoles

We developed a novel method for direct C3 carbamoylation of 2H-indazoles using oxamic acids as carbamoyl radical sources. In the presence of ammonium persulfate, carbamoyl radicals were generated from oxamic acids, then used for further reactions with 2H-indazoles to afford the desired products. The reaction proceeds under metal- and catalyst-free conditions. This simple process allows for the efficient synthesis of C3 carbamoylated 2H-indazoles, which are important scaffolds in organic synthesis.

CD4 mimics targeting the mechanism of HIV entry

A structure-activity relationship study was conducted of several CD4 mimicking small molecules which block the interaction between HIV-1 gp120 and CD4. These CD4 mimics induce a conformational change in gp120, exposing its co-receptor-binding site. This induces a highly synergistic interaction in the use in combination with a co-receptor CXCR4 antagonist and reveals a pronounced effect on the dynamic supramolecular mechanism of HIV-1 entry.

Synthesis, crystal structure, and insecticidal activity of novel N-alkyloxyoxalyl derivatives of 2-arylpyrrole

Two series of novel N-alkyloxyoxalyl derivatives of 2-arylpyrrole were synthesized, and their structures were characterized by 1H NMR spectroscopy, elemental analysis, and single-crystal X-ray diffraction analysis. The insecticidal activities of the new compounds were evaluated. The results of bioassays indicated that some of these title compounds exhibited excellent insecticidal activities, and their insecticidal activities against oriental armyworm, mosquito, and spider mite are comparable to those of the commercialized Chlorfenapyr.