42970-52-5

Basic information

• Product Name: 5-(2-methylphenyl)phenanthridin-6(5H)-one
• CAS NO: 42970-52-5
• Molecular Weight: 285.345
• Mol File: 42970-52-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5-(2-methylphenyl)phenanthridin-6(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-methylphenyl)phenanthridin-6(5H)-one(42970-52-5)
• EPA Substance Registry System: 5-(2-methylphenyl)phenanthridin-6(5H)-one(42970-52-5)

Safety Data

• Hazardous Substances Data: 42970-52-5(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 
• 88-65-3 2-bromobenzoic-acid 
• 303991-47-1 2-bromo-N-(o-tolyl)benzamide 
• 42970-52-5 (+/-)-5-(2-o-tolyl)phenanthridin-6(5H)-one 
• 15679-03-5 6-chlorophenanthridine 
• 1015-89-0 6(5H)-phenanthridinone 
• 486-25-9 9-fluorenone 
• 54970-85-3 3-(2-methylphenyl)benzo-1,2,3-triazin-4(3H)-one 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 42970-52-5 (+)-5-(2'-methylphenyl)phenanthridin-6(5H)-one 
• 42970-52-5 5-(2-methylphenyl)phenanthridin-6(5H)-one 

Relevant articles and documents

Solvent-free and transition metal catalyst-free synthesis of indolo[1,2-f]phenanthridine from 6-chlorophenanthridine

A new easily scalable synthesis of the important for materials chemistry indolo[1,2-f]phenanthridine from commercially available 6-chlorophenanthridine was developed. The suggested transition metal catalyst-free and solvent-free procedure is more ecologically friendly and cost efficient then the known methods. The yields of indolo[1,2-f]phenanthridine synthesized from 6-chlorophenanthridine in three steps were 20% and 26% if the cyclization was carried out solvent-free and in THF in the presence of lithium 2,2,6,6-tetramethylpiperidide, respectively.

Nickel-Catalyzed Denitrogenative Annulation of 1,2,3-Benzotriazin-4-(3H)-ones with Benzynes for Construction of Phenanthridinone Scaffolds

The synthesis of phenanthridinones via denitrogenative annulation of 1,2,3-benzotriazin-4-(3H)-ones with arynes catalysed by Ni(0)/dppm was successfully developed. A variety of phenanthridinones were prepared in good to excellent yields. Based on this method, nature product, N-methylcrinasidine, was synthesized. (Figure presented.).

Practical Synthesis of Phenanthridinones by Palladium-Catalyzed One-Pot C-C and C-N Coupling Reaction: Extending the Substrate Scope to o-Chlorobenzamides

A highly efficient construction of phenanthridinone derivatives from o-halobenzamides was developed by using a phosphine-free palladium catalyst in N,N-dimethylacetamide. The domino reaction proceeds through a sequential C-C and C-N bond-formation process in one pot. This protocol exhibits broad substrate scope and affords a series of phenanthridinones in up to 93 % yield. Importantly, the protocol could also be applied for the less reactive o-chlorobenzamides. The approach constitutes the first example of the synthesis of phenanthridinones from this kind of substrate. Moreover, the success of a gram-scale reaction demonstrated that this operationally simple process is scalable.