430461-23-7

Basic information

• Product Name: (3R,8R,8aR)-3,8-diphenyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
• Synonyms: (3R,8R,8aR)-3,8-diphenyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
• CAS NO: 430461-23-7
• Molecular Weight: 293.365
• Mol File: 430461-23-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,8R,8aR)-3,8-diphenyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,8R,8aR)-3,8-diphenyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine(430461-23-7)
• EPA Substance Registry System: (3R,8R,8aR)-3,8-diphenyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine(430461-23-7)

Safety Data

• Hazardous Substances Data: 430461-23-7(Hazardous Substances Data)

Upstream product

• 56613-80-0 D-2-phenylglycinol 
• 343947-52-4 methyl 5-oxo-4-phenylpentanoate 
• 332-15-0 1-(2-phenylethynyl)piperidine 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 430461-53-3 (3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-phenylpiperidine 
• 430461-56-6 (R)-3-phenyl piperidine 
• 1572246-21-9 (R)-5-{[(1R)-2-hydroxy-1-phenylethyl]amino}-4-phenyl-1-pentanol 
• 1572246-35-5 (R)-5-[(tert-butoxycarbonyl)amino]-4-phenyl-1-pentanol 

Relevant articles and documents

Dynamic kinetic resolution of racemic γ-aryl-δ-oxoesters. Enantioselective synthesis of 3-arylpiperidines

Cyclodehydration of racemic γ-aryl-δ-oxoesters with (R)- or (S)-phenylglycinol stereoselectively affords bicyclic δ-lactams, in a process that involves a dynamic kinetic resolution. Subsequent reduction of these lactams leads to enantiopure 3-arylpiperidines. Starting from racemic aldehyde esters, this short sequence has been applied to the synthesis of (R)-3-phenylpiperidine and the antipsychotic drug (-)-3-PPP (an (S)-3-arylpiperidine), whereas starting from racemic ketone esters enantiopure cis-2-alkyl-3-arylpiperidines are prepared.