4310-64-9

Basic information

• Product Name: 3-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]propane-1,2-diol
• CAS NO: 4310-64-9
• Molecular Formula: C₂₆H₂₆O₄
• Molecular Weight: 402.4822
• Mol File: 4310-64-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 600.3°C at 760 mmHg
• Flash Point: 316.8°C
• Density: 1.218g/cm³
• Vapor Pressure: 2.94E-15mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: 3-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]propane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]propane-1,2-diol(4310-64-9)
• EPA Substance Registry System: 3-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]propane-1,2-diol(4310-64-9)

Safety Data

• Hazardous Substances Data: 4310-64-9(Hazardous Substances Data)

Upstream product

• 554-10-9 3-iodo-propane-1,2-diol 
• 1729-38-0 1-(p-hydroxyphenyl)-6-methoxy-2-phenyl-3,4-dihydronaphthalene 
• 96-24-2 3-monochloro-1,2-propanediol 
• 1769-84-2 6-methoxy-2-phenyl-1-tetralone 
• 22966-24-1 1-(3-methoxyphenyl)-3-phenyl-2-propene-1-one 
• 1729-33-5 2-Phenyl-4-(3-methoxyphenyl)-4-ketobutyronitril 
• 1729-34-6 2-Phenyl-4-(3-methoxyphenyl)-4-ketobuttersaeure 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 

Relevant articles and documents

Antiestrogens and antiestrogen metabolites: Preparation of tritium-labeled (±)-cis-3-[p-(1,2,3,4-tetrahydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]-1,2-propanediol (U-23469) and characterization and synthesis of a biologically important metabolite

The Upjohn antiestrogen (±)-cis-3-[p-(1,2,3,4-tetrahydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]-1,2-propanediol (2b, U 23469) has been prepared in tritium-labeled form by reduction of an unsaturated dihydronaphthalene precursor with carrier-free tritium gas over a palladium catalyst followed by alkylation with 3-iodo-1,2-propanediol. After extensive chromatographic purification, the final material was obtained with a specific activity of 13 Ci/mmol and a radiochemical purity of 94%. In vivo studies with immature rats show that [3H]2b is slowly converted to a more polar metabolite that is selectively accumulated in the nuclear fraction of the uterus where it is bound to the estrogen receptor. Chromatographic comparisons indicate that this metabolite is a demethylated analogue, a compound that has an affinity for estrogen receptor more than 300 times greater than that of 2b. These studies suggest that the demethylated analogue may be a biologically important metabolite of 2b that is involved in the action of this antiestrogen.