433922-57-7

Basic information

• Product Name: 1-(5-Bromopyridin-2-yl)-1H-pyrazole
• Synonyms: 1-(5-Bromopyridin-2-yl)-1H-pyrazole;5-Bromo-2-(1H-pyrazol-1-yl)pyridine 98%;5-Bromo-2-(1H-pyrazol-1-yl)pyridine;5-Bromo-2-(1H-pyrazol-1-yl)pyridine98%
• CAS NO: 433922-57-7
• Molecular Formula: C₈H₆BrN₃
• Molecular Weight: 224.07
• Product Categories: blocks;Bromides;Pyridines
• Mol File: 433922-57-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 298.427°C at 760 mmHg
• Flash Point: 134.284°C
• Appearance: /
• Density: 1.635g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.683
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(5-Bromopyridin-2-yl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-Bromopyridin-2-yl)-1H-pyrazole(433922-57-7)
• EPA Substance Registry System: 1-(5-Bromopyridin-2-yl)-1H-pyrazole(433922-57-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 433922-57-7(Hazardous Substances Data)

Usage

General Description

1-(5-Bromopyridin-2-yl)-1H-pyrazole is a chemical compound with the molecular formula C8H6BrN3. 1-(5-Bromopyridin-2-yl)-1H-pyrazole, classified under the broad category of organobromides and organoheterocyclic compounds, features a pyrazole moiety - a class of organic compounds characterized by a 5-membered aromatic ring with two nitrogen atoms and three carbon atoms. Its pyridinyl part with a bromine atom shows that it also belongs to halogenated pyridines. 1-(5-Bromopyridin-2-yl)-1H-pyrazole is likely to be used in the synthesis of other complex compounds in the field of organic chemistry, such as pharmaceuticals, agrochemicals, or functional materials. Its properties, toxicity, or environmental impact are not typically covered in databases, necessitating specific studies.

InChI:InChI=1/C8H6BrN3/c9-7-2-3-8(10-6-7)12-5-1-4-11-12/h1-6H

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 288-13-1 NH-pyrazole 
• 380380-69-8 5-bromo-2-(1H-1,2,3-triazol-1-yl)pyridine 
• 383142-29-8 5-bromo-2-(1H-pyrrol-1-yl)pyridine 
• 1043906-08-6 1-(5-bromopyridin-2-yl)-1H-benzo[d]imidazole 
• 380381-18-0 5-bromo-2-(1H-imidazol-1-yl)pyridine 
• 766-11-0 5-bromo-2-fluoropyridine 

Downstream Products

• 1218791-02-6 2-(1H-pyrazol-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 1416000-02-6 2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)-10-(3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one 
• 1351523-97-1 4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)-N-cyclopropylthiazol-2-amine 

Relevant articles and documents

Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines

A novel series of amide functionalized imidazo[1,2-a]pyridine (14a–14j) derivatives were synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB-231), lung (A549), and prostate (DU-145) cancer cell lines using MTT assay with etoposide as the standard reference drug. Among them, compound 14j showed highest potency in anticancer activities against MCF-7, MDA-MB-231, A549, and DU-145 cell lines with IC50 values of 0.021 ± 0.0012 μM, 0.95 ± 0.039 μM, 0.091 ± 0.0053 μM, and 0.24 ± 0.032 μM, respectively.

PYRIDONAPHTHYRIDINE PI3K/MTOR DUAL INHIBITORS AND PREPARATION AND USE THEREOF

The present invention relates to a pyridonaphthyridine compound as represented by general formula (I), which has a dual PI3K and mTOR inhibition effect, and its pharmaceutically acceptable salt, stereoisomer and deuteride thereof, wherein R1, R2, R3, R4, R5, R6, R7 and X are as defined in the specification; the present invention also relates to a method for preparing said compound, a pharmaceutical composition and a pharmaceutical formulation containing said compound, and uses of said compound in treating and/or preventing a proliferative disease and in the manufacture of a medicament for treating and/or preventing a proliferative disease.

6-O-carbamoyl ketolide antibacterials

6-O-Carbamoyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, R5, R6, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.